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Past TB that has never been treated has a higher risk of progressing than does latent <jats:italic>Mycobacterium tuberculosis<\/jats:italic> infection in patients who have previously received treatment. Antibody responses against 23 kinds of <jats:italic>M. tuberculosis<\/jats:italic> proteins in individuals with past TB who had not been medicated were evaluated. These individuals had significantly higher concentrations of antibodies against Antigen 85A and mycobacterial DNA\u2010binding protein 1 (MDP1) than did those with active TB and uninfected controls. In addition, immunohistochemistry revealed colocalization of tubercle bacilli, antigen 85 and MDP1 inside tuberculous granuloma lesions in an asymptomatic subject, showing that <jats:italic>M. tuberculosis<\/jats:italic> in lesions expresses both antigen 85 and MDP1. Our study suggests the potential usefulness of measuring antibody responses to antigen 85A and MDP1 for assessing the risk of TB progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1348-0421.2012.12005.x","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T14:45:30Z","timestamp":1353077130000},"page":"30-37","source":"Crossref","is-referenced-by-count":18,"title":["Antigen 85A and mycobacterial DNA\u2010binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis"],"prefix":"10.1111","volume":"57","author":[{"given":"Mayuko","family":"Osada\u2010Oka","sequence":"first","affiliation":[{"name":"Department of Bacteriology Osaka City University Graduate School of Medicine 1\u20104\u20103 Abeno\u2010ku, Osaka 545\u20108585"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Bacteriology Osaka City University Graduate 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