{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:28:25Z","timestamp":1764782905016},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T00:00:00Z","timestamp":1124755200000},"content-version":"vor","delay-in-days":2395,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Cancer Research"],"published-print":{"date-parts":[[1999,2]]},"abstract":"<jats:p>The effect of persistent hepatitis C viremia on the outcome after resection of hepatocellular carcinoma (HCC) was investigated in 59 consecutive patients with a single small HCC (??3.0 cm in diameter). The presence of serum hepatitis C virus (HCV) RNA was evaluated using a reverse transcription polymerase chain reaction method as well as a branched DNA probe method. Clinicopathologic findings were compared between patients with and without viremia and the risk factors for poor outcome were evaluated. Hepatitis C virus (HCV) RNA was not detected in the sera from 7 patients (group 1), but was detected in the sera from the other 52 patients (group 2). Alanine a minotransferase (ALT) activity was significantly higher in group 2 than in group 1. The proportion of patients with active hepatitis was significantly higher in group 2. In group 2, new HCC often developed after the operation and four patients died of liver dysfunction. HCV viremia, high ALT activity, high concentration of total bilirubin, and liver cirrhosis were related to recurrence after the operation. Multivariate analysis indicated that HCV viremia and high ALT activity were independent risk factors for recurrence of HCC. Continuous hepatitis with persistent HCV viremia worsened the outcome after the resection of HCC by causing new development of HCC and deterioration of liver function. In patients with HCV\u2010related HCC, but without HCV viremia, satisfactory results can be expected after liver resection.<\/jats:p>","DOI":"10.1111\/j.1349-7006.1999.tb00729.x","type":"journal-article","created":{"date-parts":[[2005,8,23]],"date-time":"2005-08-23T09:05:37Z","timestamp":1124787937000},"page":"162-170","source":"Crossref","is-referenced-by-count":30,"title":["Effects of Continuous Hepatitis with Persistent Hepatitis C Viremia on Outcome after Resection of Hepatocellular Carcinoma"],"prefix":"10.1111","volume":"90","author":[{"given":"Shoji","family":"Kubo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nishiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Shuto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadashi","family":"Tsukamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hirohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ikebe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kuroki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,23]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"277","article-title":"Primary liver cancer in Japan: clinicopathological features and results of surgical treatment","volume":"211","author":"Liver Cancer Study Group of Japan","year":"1990","journal-title":"Ann. Surg."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140510"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199108000-00004"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840160611"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90724-Q"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90419-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250116"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930101)71:1<19::AID-CNCR2820710105>3.0.CO;2-I"},{"key":"e_1_2_1_10_2","first-page":"328","article-title":"Long\u2010term results after resection of hepatocellular carcinoma: experience of 480 cases","volume":"40","author":"Kosuge T.","year":"1993","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90707-2"},{"key":"e_1_2_1_12_2","first-page":"222","article-title":"Surgical treatment and prognostic variables of hepatocellular carcinoma in 122 cirrhotics","volume":"42","author":"Di Carlo V.","year":"1995","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951215)76:12<2443::AID-CNCR2820761207>3.0.CO;2-F"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199603000-00011"},{"key":"e_1_2_1_15_2","first-page":"1271","article-title":"Detection of replicative hepatitis C virus sequences in hepatocellular carcinoma","volume":"141","author":"Gerber M. A.","year":"1992","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.6.828"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840140227"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02899246"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(95)00034-N"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1994.tb02903.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(98)70259-4"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970215)79:4<688::AID-CNCR5>3.0.CO;2-A"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1998.tb00580.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510250138"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6346(97)00090-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840130606"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150108"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840150607"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91739-X"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80446-3"},{"key":"e_1_2_1_31_2","volume-title":"\u201cThe General Rules for the Clinical and Pathological Study of Primary Liver Cancer","author":"Liver Cancer Study Group of Japan","year":"1992"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090516"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190629"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(97)90313-5"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817"},{"key":"e_1_2_1_37_2","first-page":"1504","article-title":"Different pattern of chromosomal allele loss in multiple hepatocellular carcinomas as evidence of their multifocal orgin","volume":"52","author":"Tsuda H.","year":"1992","journal-title":"Cancer Res."},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/0928-4346(93)90050-P"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190414"},{"key":"e_1_2_1_40_2","doi-asserted-by":"crossref","unstructured":")Kubo S. Kinoshita H. Hirohashi K. Tanaka H. Tsukamoto T. Hamba H. Shuto T. Yamamoto T. Ikebe T.andWakasa K.Patterns of and risk factors for recurrence after live resection for well\u2010differentiated hepatocellular carcinoma: a special reference to multicentric carcinogenesis after operation.Hepatogastroenterology(1999). in press .","DOI":"10.1007\/s002680010277"},{"issue":"1004","key":"e_1_2_1_41_2","first-page":"1006","article-title":"Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis","author":"Bruix J.","year":"1989","journal-title":"Lancet"},{"issue":"1006","key":"e_1_2_1_42_2","first-page":"1008","article-title":"Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma","author":"Colombo M.","year":"1989","journal-title":"Lancet"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910115)67:2<429::AID-CNCR2820670218>3.0.CO;2-#"},{"key":"e_1_2_1_44_2","unstructured":")Kubo S. Nishiguchi S. Hirohashi K. Tanaka H. Tsukamoto T. Hamba H. Shuto T. Okuda T. Tamori A. Kuroki T.andKuroki T.High prevalence of hepatitis B and C viruses in patients with hepatocellular carcinoma in Japan.Hepatogastroenterology(1999) in press ."},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180116"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(96)80022-5"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1997.tb00398.x"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840170307"}],"container-title":["Japanese Journal of Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.1999.tb00729.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.1999.tb00729.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T15:25:30Z","timestamp":1698506730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.1999.tb00729.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,2]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,2]]}},"alternative-id":["10.1111\/j.1349-7006.1999.tb00729.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.1999.tb00729.x","archive":["Portico"],"relation":{},"ISSN":["0910-5050"],"issn-type":[{"value":"0910-5050","type":"print"}],"subject":[],"published":{"date-parts":[[1999,2]]}}}