{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:30:22Z","timestamp":1772814622021,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T00:00:00Z","timestamp":1124668800000},"content-version":"vor","delay-in-days":2000,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Cancer Research"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>The reported regression of mucosa\u2010associated lymphoid tissue (MALT) type gastric low\u2010grade Bcell lymphoma following treatment for <jats:italic>Helicobacter pylori (H. pylori)<\/jats:italic> infection has not yet been comprehensively analyzed, especially in relation to the recently identified <jats:italic>c\u2010IAP2\u2010MALT1\/MLT<\/jats:italic> gene alteration resulting from the t(11;18)(q21;q21) chromosomal translocation found in MALT lymphoma. The relationship between MALT lymphomas and <jats:italic>H. pylori<\/jats:italic> was investigated in 30 patients who received an antibacterial treatment. Patients were followed up by means of endoscopy and biopsy. Molecular genetic analyses focused on the presence or absence of the immunoglobulin heavy chain (IgH) gene and\/or <jats:italic>MALT1\/MLT<\/jats:italic> gene alteration resulting from t(11;18)(q21;q21) translocation. <jats:italic>H. pylori<\/jats:italic> was positive in 26 of the 30 patients. The overall success rate of cure of <jats:italic>H. pylori<\/jats:italic> infection was 96% (25\/26). Thirteen patients (52%) showed complete remission (CR) of lymphoma, nine (36%) partial remission (PR), and three (12%) registered no change (NC). Statistical analysis revealed significant differences between CR and PR\/NC patients in age (&lt; 60 or 60), in lymphoma location (single or multiple sites) and in the presence or absence of gene rearrangement before eradication (<jats:italic>P<\/jats:italic>&lt; 0.05). Endoscopy showed a cobblestone appearance only in PR cases and polypoid features predominantly in NC cases. Two NC patients with polypoid gross appearance showed rearrangements involving either <jats:italic>c\u2010IAP2<\/jats:italic> or <jats:italic>MALT1<\/jats:italic> gene in Southern blot analysis, while none of seven other resected patients with non\u2010polypoid superficial gross appearance showed rearrangement. Gastric MALT lymphoma could be pragmatically subdivided into three groups, CR (MALT\u2010A), PR (MALT\u2010B), and NC (MALT\u2010C) on the basis of the reaction to eradication of <jats:italic>H.pylori.<\/jats:italic> We speculate that MALT\u2010A may represent an incipient neoplasm or dysplasia, MALT\u2010B a neoplasm activated by antigenic stimulation of <jats:italic>H. pylori<\/jats:italic>, and MALT\u2010C a lymphoma independent of <jats:italic>H. pylori.<\/jats:italic> Polypoid lesions in MALT\u2010C were associated with <jats:italic>c\u2010IAP2\u2010MALT1\/MLT<\/jats:italic> gene alteration resulting from t(11;18)(q21;q21). This classification is thought to be clinically significant for deciding the most appropriate mode of treatment of MALT\u2010type lymphoproliferative disorders.<\/jats:p>","DOI":"10.1111\/j.1349-7006.2000.tb00945.x","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T12:08:08Z","timestamp":1124712488000},"page":"301-309","source":"Crossref","is-referenced-by-count":50,"title":["<i>Helicobacter pylori<\/i> and the t(11;18)(q21;q21) Translocation in Gastric Low\u2010grade B\u2010Cell Lymphoma of Mucosa\u2010associated Lymphoid Tissue Type"],"prefix":"10.1111","volume":"91","author":[{"given":"Tsuneya","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakatsu","family":"Yonezumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Yatabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takio","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ohashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91409-F"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405053301803"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.5.436"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1182\/blood.V87.4.1255.bloodjournal8741255","article-title":"Diagnosis and post\u2010treatment follow up of Helicobacter pylori\u2010positive gastric lymphoma of mucosa\u2010associated lymphoid tissue: histology, polymerase chain reaction, or both","volume":"87","author":"Savio A.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90113-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90828-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90679-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199509000-00011"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-10-199505150-00006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9322502"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203018"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058869"},{"key":"e_1_2_1_15_2","first-page":"1351","article-title":"Poor correlation between clonal immunoglobulin gene rearrangement and immunoglobulin gene transcription in Hodgkin's disease","volume":"149","author":"Yatabe Y.","year":"1996","journal-title":"Am. 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