{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T09:12:52Z","timestamp":1698657172306},"reference-count":43,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T00:00:00Z","timestamp":1124668800000},"content-version":"vor","delay-in-days":2000,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Cancer Research"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p>The expression of thymidine phosphorylase (TP) in carcinoma of the papilla of Vater was studied to clarify its significance in tumor progression and in determining prognosis. Fifty\u2010nine cases of surgically resected carcinoma of the papilla of Vater were studied. Immunohistochemical staining was performed to evaluate the expression of TP, microvessel count and p53 overexpression. TP expression was demonstrated in tumor cells in 62.7% (37\/59) of the cases. A higher frequency of regional lymph node metastasis was found in TP\u2010positive tumors than in TP\u2010negative tumors (<jats:italic>P<\/jats:italic>=0.006). TP\u2010positive tumors were more advanced than TP\u2010negative tumors with regard to clinical stage (<jats:italic>P<\/jats:italic>=0.035). TP\u2010positive tumors had significantly higher microvessel density (27.6\u00b110.1) than TP\u2010negative tumors (20.4\u00b110.0, <jats:italic>P<\/jats:italic>=0.01). Moreover, TP expression was significantly correlated with a poor prognosis (<jats:italic>P<\/jats:italic>=0.02). These suggest that in carcinoma of the papilla of Vater, TP production by tumor cells is correlated with tumor progression through its regulatory effect on neovascularization.<\/jats:p>","DOI":"10.1111\/j.1349-7006.2000.tb00949.x","type":"journal-article","created":{"date-parts":[[2005,8,22]],"date-time":"2005-08-22T12:08:08Z","timestamp":1124712488000},"page":"331-336","source":"Crossref","is-referenced-by-count":1,"title":["Significance of Thymidine Phosphorylase\/Platelet\u2010derived Endothelial Cell Growth Factor in Carcinoma of the Papilla of Vater"],"prefix":"10.1111","volume":"91","author":[{"given":"Bin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Futakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joji","family":"Kitayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Nagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Makuuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,22]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420050081010"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80197-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880401)61:7<1394::AID-CNCR2820610720>3.0.CO;2-M"},{"key":"e_1_2_1_5_2","first-page":"260","article-title":"Clinicopathological characteristics and surgical procedures for carcinoma of the papilla of Vater","volume":"43","author":"Futakawa N.","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_1_6_2","first-page":"1163","article-title":"Neoplasia of the ampulla of Vater. 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