{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T16:29:42Z","timestamp":1791044982306,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T00:00:00Z","timestamp":1124409600000},"content-version":"vor","delay-in-days":475,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:p>HTLV\u2010I is the causative agent of adult T\u2010cell leukemia (ATL). However, the precise mechanism underlying the neoplastic cell growth of ATL remains unclear. In this study, we established a leukemic cell line, termed SYK\u201011L(+), from tumor cells (S\u2010YU) in an <jats:italic>in vivo<\/jats:italic> cell proliferation model of ATL using severe combined immunodeficiency (SCID) mice. Unexpectedly, SYK\u201011L(+) was found to have no tumorigenicity in SCID mice. Flow cytometric analysis showed that S\u2010YU expressed cell adhesion molecules including CD44, ICAM\u20101 and OX40, whereas SYK\u201011L(+) had lost the expression of these molecules. The administration of anti\u2010OX40 monoclonal antibody inhibited the engraftment of S\u2010YU cells into SCID mice, suggesting that OX40 is a potential target for immunotherapy. Significant differences in responsiveness to IL\u20102 and IL\u201015 were observed between the two cell types. To better understand the molecular basis of tumorigenicity, cDNA microarray analysis was performed using tumorigenic S\u2010YU and non\u2010tumori\u2010genic SYK\u201011L(+) cells. We obtained several candidate genes differentially overexpressed in S\u2010YU compared with SYK\u201011L(+). Interestingly, one such gene, regulator of G protein signaling 1 (RGS1), was shown to be overexpressed in most ATL patients. Further characterization of the differentially expressed molecules, such as OX40 and RGS1, would provide useful information not only to elucidate the mechanism of ATL cell growth <jats:italic>in vivo<\/jats:italic>, but also to develop novel molecularly targeted therapies.<\/jats:p>","DOI":"10.1111\/j.1349-7006.2004.tb03224.x","type":"journal-article","created":{"date-parts":[[2005,8,19]],"date-time":"2005-08-19T10:11:51Z","timestamp":1124446311000},"page":"411-417","source":"Crossref","is-referenced-by-count":22,"title":["Identification of differentially expressed molecules in adult T\u2010cell leukemia cells proliferating <i>in 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