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Although the precise mechanism of cell transformation is unclear, the HTLV\u20101\u2010encoded protein, Tax, is thought to play a crucial role in leukemogenesis. Here we demonstrate that lymphocytes isolated from patients with ATL show centrosome amplification and that a human T cell line shows centrosome amplification after induction of Tax, which was suppressed by CDK inhibitors. Micronuclei formation was also observed after centrosome amplification in Tax\u2010induced human T cells. These findings suggest that Tax deregulates CDK activity and induces centrosome amplification, which might be associated with cellular transformation by HTLV\u20101 and chromosomal instability in HTLV\u20101\u2010infected human T cells. (<jats:italic>Cancer Sci<\/jats:italic> 2006; 97: 836\u2013841)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2006.00254.x","type":"journal-article","created":{"date-parts":[[2006,6,29]],"date-time":"2006-06-29T15:33:03Z","timestamp":1151595183000},"page":"836-841","source":"Crossref","is-referenced-by-count":35,"title":["Centrosome amplification in adult T\u2010cell leukemia and human T\u2010cell leukemia virus type 1 Tax\u2010induced human T 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