{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:46:31Z","timestamp":1762865191485},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T00:00:00Z","timestamp":1157414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p>The present study was carried out in order to examine the molecular status of selected growth factor receptors (GFR) in urinary bladder lesions, recently described by our group as representing \u2018Chernobyl cystitis\u2019. Fibroblast growth factor receptor 3 (FGFR3), epidermal growth factor receptor 1 (EGFR1), EGFR2<jats:italic>neu<\/jats:italic> (a member of the same family), p53 and Raf\u20101 serine\/threonine kinase expression were evaluated immunohistochemically in urinary bladder biopsies from 22 men with benign prostate hyperplasia (group 1). For comparison, 16 men with benign prostate hyperplasia and five women with chronic cystitis living in non\u2010radio\u2010contaminated areas of the country were also investigated as controls (group 2). Additionally, 14 patients with dysplasia, carcinoma <jats:italic>in\u00a0situ<\/jats:italic> (CIS) and primary urothelial carcinoma (UC) operated before the Chernobyl accident as well as 23 patients with UC living in the radio\u2010contaminated areas were included as pre\u2010 and post\u2010Chernobyl UC groups 1 and 2, respectively. Chronic proliferative atypical cystitis (\u2018Chernobyl cystitis\u2019) was observed in group 1 patients. Foci of dysplasia and CIS were found in 22 (100%) and 19 (86%) of the 22 cases, respectively; moreover, two small UC were also detected. Elevated levels of FGFR3, EGFR2\/<jats:italic>neu<\/jats:italic>, p53 and to a lesser extent EGFR1 and Raf\u20101 expression in the urothelial dysplasia and CIS were evident for patients of group 1. Statistically significant differences in immunohistochemical scores for FGFR3, EGFR1, p53 and Raf\u20101 were observed between groups 1 and 2 and between group 1 and the post\u2010Chernobyl UC group 2, where a change in expression of EGFR2\/<jats:italic>neu<\/jats:italic> was also noted. A significant decrease in FGFR3 expression in additional pre\u2010Chernobyl UC group 1 with dysplasia, CIS and UC compared with group 1 Chernobyl cystitis cases was detected. Our findings suggest that FGFR and EGFR signaling pathways, associated with p53 and Raf\u20101 activation, may contribute to multistage urothelial carcinogenesis caused by irradiation, through autocrine or paracrine growth stimulation. (<jats:italic>Cancer Sci<\/jats:italic> 2006; 97: 1168\u20131174)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2006.00309.x","type":"journal-article","created":{"date-parts":[[2006,9,5]],"date-time":"2006-09-05T08:18:19Z","timestamp":1157444299000},"page":"1168-1174","source":"Crossref","is-referenced-by-count":6,"title":["Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf\u20101, in urothelial dysplasia and carcinoma <i>in\u00a0situ<\/i> after the Chernobyl accident"],"prefix":"10.1111","volume":"97","author":[{"given":"Alina M.","family":"Romanenko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichirou","family":"Morimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Wanibuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wadim K.","family":"Zaparin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladimir I.","family":"Vinnichenko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander F.","family":"Vozianov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Fukushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,9,5]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"1433","article-title":"The results and prospects of the automated follow\u2010up of the dispensary care of cancer patients","volume":"34","author":"Okeanov AE","year":"1988","journal-title":"Vopr Onkol"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004032-199108000-00013"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/35020248"},{"key":"e_1_2_7_5_2","first-page":"280","article-title":"Epidemiology of primary liver cancer in the Belarus Republic","volume":"44","author":"Zhavoronok SV","year":"1998","journal-title":"Vopr Onkol"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64554-5"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01441.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000615)86:6<790::AID-IJC6>3.0.CO;2-Q"},{"key":"e_1_2_7_9_2","first-page":"3606","article-title":"Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident","volume":"59","author":"Yamamoto S","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_7_10_2","first-page":"9","article-title":"Urogenital tuberculosis in the Ukraine population","volume":"5","author":"Pavlova LP","year":"1999","journal-title":"Probl Tuberk"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1667\/0033-7587(2003)159[0283:SARIAO]2.0.CO;2"},{"key":"e_1_2_7_12_2","first-page":"1265","article-title":"The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate","volume":"61","author":"Van Rhijn BW","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.073"},{"key":"e_1_2_7_14_2","first-page":"1957","article-title":"Expression profiles of ErbB family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder","volume":"7","author":"Chow NH","year":"2001","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_15_2","first-page":"6227","article-title":"A subclass of HER1 ligands are prognostic markers for survival in bladder cancer patients","volume":"61","author":"Thogersen VB","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_7_16_2","first-page":"277","article-title":"[Comparative study of p53, Bcl\u20102, and C\u2010erbB\u20102 expression in low\u2010grade papillary bladder tumors.]","volume":"56","author":"Ramos Soler D","year":"2003","journal-title":"Arch Esp Urol"},{"key":"e_1_2_7_17_2","first-page":"788","article-title":"Absence of HER2\/neu gene expression in osteosarcoma and skeletal Ewing's sarcoma","volume":"8","author":"Thomas DG","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.7.4378"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/369411a0"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.7.1251"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000055273"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.17.1331"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0094-0143(21)00398-0","article-title":"Carcinoma of the male and female urethra","volume":"19","author":"Mostofi FK","year":"1992","journal-title":"Urol Clin North Am"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19971101)80:9<1803::AID-CNCR16>3.0.CO;2-9"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365598809180797"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64665-2"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205935"},{"key":"e_1_2_7_28_2","first-page":"734","article-title":"Differential expression of growth factors in squamous cell carcinoma and precancerous lesions of the lung","volume":"8","author":"Piyathilake CJ","year":"2002","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206698"},{"key":"e_1_2_7_30_2","first-page":"405","article-title":"The inducible expression of dominant\u2010negative epidermal growth factor receptor\u2010CD533 results in radiosensitization of human mammary carcinoma cells","volume":"5","author":"Contessa JN","year":"1999","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.01.504"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60765-4"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.2006.00309.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.2006.00309.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T18:53:45Z","timestamp":1697396025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.2006.00309.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,5]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1349-7006.2006.00309.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.2006.00309.x","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,5]]}}}