{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T16:00:00Z","timestamp":1771862400625,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>To clarify the clinical presentation and outcome of nodal marginal zone B\u2010cell lymphoma (NMZBL), 65 Japanese patients with this disease were studied and compared with the published literature from western countries. The clinical findings of our 65 cases were similar to those of their cases in some aspects: (1) 58% of the patients were &gt;60\u00a0years old (median age, 64\u00a0years); (2) there was a slight female predominance; (3) 90% of the patients exhibited asymptomatic lymphadenopathy in the head and neck area; (4) only a minority of patients had B symptoms (6%) and poor performance status (8%); and (5) only 5% of patients were positive for M\u2010protein. However, the 65 patients in this series exhibited relatively longer 5\u2010year overall survival (85%) and failure\u2010free survival (60%) than the NMZBL series published in western literature, suggesting that NMZBL should be classified as indolent lymphoma. Moreover, based on the histological findings, we further classified four histological subtypes as follows: (1) splenic type (<jats:italic>n<\/jats:italic>\u00a0=\u00a07); (2) floral type (<jats:italic>n<\/jats:italic>\u00a0=\u00a09); (3) mucosa\u2010associated lymphoid tissue (MALT) type (<jats:italic>n<\/jats:italic>\u00a0=\u00a029); and (4) diffuse large B\u2010cell lymphoma (DLBCL)\u00a0+\u00a0MALT type (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). DLBCL\u00a0+\u00a0MALT type exhibited significantly poorer 5\u2010year overall survival than the splenic variant. The recognition of DLBCL\u00a0+\u00a0MALT type appears important. No API2\u2013MALT1 fusion transcript was detected in any of the 14 cases examined. (<jats:italic>Cancer Sci<\/jats:italic> 2007; 98: 44\u201349)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2006.00345.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T09:31:01Z","timestamp":1161163861000},"page":"44-49","source":"Crossref","is-referenced-by-count":33,"title":["Clinical implications of nodal marginal zone B\u2010cell lymphoma among Japanese: study of 65 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