{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:50:42Z","timestamp":1768557042009,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T00:00:00Z","timestamp":1166572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>Tumor\u2010related angiogenesis is likely to be a potential target for the treatment of cancer. One key to develop this angiostatic strategy would be to find useful angiogenesis inhibitors. Here we report the effects of radicicol, a microbial angiogenesis inhibitor that we previously identified using the chorioallantoic membrane assay, and its novel analog, 14,16\u2010dipalmitoyl\u2010radicicol, on tumor angiogenesis and growth. As expected for agents containing a penolic hydroxyl group, systemic administration of radicicol had little or no effect on neovascularization triggered by a M5076 mouse tumor cell line or a RMT\u20101 rat mammary carcinoma cell line established from autochthonous rat mammary tumors induced by 7,12\u2010dimethylbenz[a]anthracene in a mouse dorsal air sac assay system. The agent did not show growth\u2010inhibitory activity against either transplantable M5076 tumors or autochthonous 7,12\u2010dimethylbenz[a]anthracene\u2010induced rat mammary tumors. In contrast, 14,16\u2010dipalmitoyl\u2010radicicol potently suppressed tumor angiogenesis and growth in these experimental models. Furthermore, the analog significantly prolonged the survival rate of M5076\u2010implanted mice. Although not stronger than radicicol, it dose\u2010dependently inhibited embryonic angiogenesis in the chorioallantoic membrane assay, the dose required for half\u2010maximal inhibition (ID<jats:sub>50<\/jats:sub>) value being 23\u00a0\u00b5g (27\u00a0nmol) per egg, and showed concentration\u2010dependent antiproliferative activity against microvascular endothelial cells <jats:italic>in\u00a0vitro<\/jats:italic>. These data suggest that 14,16\u2010dipalmitoyl\u2010radicicol is a promising antitumor agent with antiangiogenic activity. (<jats:italic>Cancer Sci<\/jats:italic> 2007; 98: 219\u2013225)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2006.00359.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T05:53:28Z","timestamp":1166680408000},"page":"219-225","source":"Crossref","is-referenced-by-count":8,"title":["Dipalmitoylation of radicicol results in improved efficacy against tumor growth and angiogenesis 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