{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:14:40Z","timestamp":1791141280634,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T00:00:00Z","timestamp":1166140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p>\n                    In an earlier report, we demonstrated overexpression of a short isoform of Helios, Hel\u20105, which lacks three of four N\u2010terminal zinc fingers, in patients with adult T\u2010cell leukemia\/lymphoma. Here, we characterized Hel\u20105 using immunoprecipitation, and gel shift and luciferase promoter assays, and found that Hel\u20105 lacks the repressor function observed with a full\u2010length isoform of Helios. Moreover, Hel\u20105 associates with the full\u2010length isoforms of the\n                    <jats:italic>Ikaros<\/jats:italic>\n                    gene family, Ikaros, Aiolos and Helios, and inhibits their DNA binding activity when present in excess, leading to dominant\u2010negative effects on the full\u2010length isoforms of the\n                    <jats:italic>Ikaros<\/jats:italic>\n                    gene family. Our results suggest a critical role for Helios in the mechanism of leukemogenesis. (\n                    <jats:italic>Cancer Sci<\/jats:italic>\n                    2007; 98: 182\u2013188)\n                  <\/jats:p>","DOI":"10.1111\/j.1349-7006.2006.00372.x","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T04:17:58Z","timestamp":1166156278000},"page":"182-188","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the short isoform of Helios overexpressed in patients with T\u2010cell malignancies"],"prefix":"10.1111","volume":"98","author":[{"given":"Takayuki","family":"Tabayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Ishimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itaru","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Kozuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsune","family":"Tanimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,15]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90407-3"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90170-1"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80269-1"},{"key":"e_1_2_6_5_2","first-page":"3931","article-title":"Decreases in Ikaros activity correlate with blast crisis in patients with chronic myelogenous leukemia","volume":"59","author":"Nakayama H","year":"1999","journal-title":"Cancer Res"},{"key":"e_1_2_6_6_2","first-page":"4062","article-title":"Dominant\u2010negative isoform of Ikaros gene in patients with adult B\u2010cell acute lymphoblastic leukemia","volume":"60","author":"Nakase K","year":"2000","journal-title":"Cancer Res"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.14.12.8292"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00920.x"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.8.2004"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80637-8"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.6.782"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70202-7"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(01)00796-2"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04216.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1182\/blood.V89.11.4136","article-title":"The type 2 CD10\/neutral endopeptidase 24.11 promoter: functional characterization and tissue\u2010specific regulation by CBF\/NF\u2010Y isoforms","volume":"89","author":"Ishimaru F","year":"1997","journal-title":"Blood"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111371200"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M000254200"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.2006.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.2006.00372.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T12:46:33Z","timestamp":1695905193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.2006.00372.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,15]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1349-7006.2006.00372.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.2006.00372.x","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,15]]}}}