{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T08:40:53Z","timestamp":1697272853707},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T00:00:00Z","timestamp":1190764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p>Adult T\u2010cell leukemia\/lymphoma (ATLL) is a human malignancy associated with human T\u2010cell leukemia virus type 1 (HTLV\u20101). The pathological features of the lymph nodes of ATLL change from those of lymphadenitis to Hodgkin's\u2010like features and those of lymphoma. Chemokines and their receptors are closely associated with T\u2010cell subgroups and immune responses. To clarify the relationship between chemokines and their receptor expression, as well as the development of ATLL, 17 cases with ATLL were analyzed using DNA chips of chemokines and their receptors. All cases showed a varied and mixed pattern of upregulated and downregulated gene expression of <jats:italic>Th1, Th2<\/jats:italic>, na\u00efve, and cytotoxic cell\u2010associated chemokine genes. As CC chemokine ligand 18 (CCL18) accounted for the most upregulated gene and CX3C chemokine receptor 1 (CX3CR1) for the most downregulated gene, they were selected for immunohistochemical analysis. Immunohistochemical staining showed expression of the two genes in immunological cells, with a positive expression for reticulum cells, but not for ATLL cells. HTLV\u20101\u2010associated lymphadenitis type (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) and Hodgkin's\u2010like type (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) cases showed significantly higher CCL18 expression than the non\u2010specific lymphadenitis cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a010) (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05). However, all HTLV\u20101\u2010associated cases showed significantly lower CX3CR1 expression than the non\u2010specific lymphadenitis cases (<jats:italic>P\u00a0&lt;<\/jats:italic>\u00a00.05). These results suggest that upregulation of CCL18 expression and downregulation of CX3CR1 expression play a role in immune responses against the ATLL cells. (<jats:italic>Cancer Sci<\/jats:italic> 2007; 98: 1875\u20131880)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2007.00627.x","type":"journal-article","created":{"date-parts":[[2007,9,26]],"date-time":"2007-09-26T13:36:30Z","timestamp":1190813790000},"page":"1875-1880","source":"Crossref","is-referenced-by-count":6,"title":["Upregulation of CC chemokine ligand 18 and downregulation of CX3C chemokine receptor 1 expression in human T\u2010cell leukemia virus type 1\u2010associated lymph node lesions: Results of chemokine and chemokine receptor DNA chip analysis"],"prefix":"10.1111","volume":"98","author":[{"given":"Kei","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kennosuke","family":"Karube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiko","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Komatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryosuke","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ohshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,26]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"97","article-title":"Overview of adult T\u2010cell leukemia\/lymphoma","volume":"25","author":"Takatsuki K.","year":"1985","journal-title":"Jpn Soc Res"},{"key":"e_1_2_7_3_2","first-page":"37","article-title":"Biopsy of adult T cell leukemia","volume":"28","author":"Kikuchi M","year":"1982","journal-title":"Gann Mono Can Res"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<539::AID-PATH465>3.0.CO;2-T"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920101)69:1<239::AID-CNCR2820690139>3.0.CO;2-#"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910315)67:6<1622::AID-CNCR2820670625>3.0.CO;2-1"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970807)72:4<592::AID-IJC7>3.0.CO;2-L"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1505"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.1.30"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20266"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5235.467"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2150"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19990909)82:6<868::AID-IJC16>3.0.CO;2-W"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00761.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-05-1352"},{"key":"e_1_2_7_17_2","first-page":"4639","article-title":"Defective provirus form of human T\u2010cell leukemia virus type I in adult T\u2010cell leukemia\/lymphoma: clinicopathological features","volume":"51","author":"Ohshima K","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(99)03014-1"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19960328)66:1<18::AID-IJC4>3.0.CO;2-1"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208979"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.2177\/jsci.28.131"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.12.6173"},{"issue":"1","key":"e_1_2_7_23_2","first-page":"S54","article-title":"Cytotoxic T cell response and expression of the target antigen in HTLV\u2010I infection","volume":"8","author":"Kannagi M","year":"1994","journal-title":"Leukemia"},{"key":"e_1_2_7_24_2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.4049\/jimmunol.133.2.1037","article-title":"Specific cytolysis of fresh tumor cells by an autologous killer T cell line derived from an adult T cell leukemia\/lymphoma patient","volume":"133","author":"Kannagi M","year":"1984","journal-title":"J Immunol"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04999.x"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04653.x"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63564-X"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.031"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112275200"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1204712"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22536"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.2007.00627.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.2007.00627.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T08:50:07Z","timestamp":1697187007000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.2007.00627.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,26]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["10.1111\/j.1349-7006.2007.00627.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.2007.00627.x","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,26]]}}}