{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:49:41Z","timestamp":1790232581273,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T00:00:00Z","timestamp":1215129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2008,9]]},"abstract":"<jats:p>Gastric mucosa\u2010associated lymphoid tissue (MALT) lymphoma is a distinct low\u2010grade lymphoma that often regresses upon <jats:italic>Helicobacter pylori<\/jats:italic> eradication. It was reported that the chemokine receptor CXCR3 is expressed not only on activated T cells, but also on MALT lymphoma cells, and that CXCR3\u2010positive B lymphocytes migrate or home to the MALT of MALT lymphoma. In the present study, we aimed to elucidate the correlation between CXCR3 expression and the clinicopathological features of gastric MALT lymphoma, and to determine whether CXCR3 expression was predictive of responsiveness to <jats:italic>H.\u00a0pylori<\/jats:italic> eradication. Sixty\u2010seven patients with gastric MALT lymphoma in a single\u2010center study were treated with <jats:italic>H.\u00a0pylori <\/jats:italic>eradication therapy. We evaluated the correlation of CXCR3 expression with response to <jats:italic>H.\u00a0pylori <\/jats:italic>eradication therapy by logistic regression stratified according to potential confounders. Immunohistochemical analysis revealed that 28 of 67 cases (42%) were positive for CXCR3 expression. CXCR3 expression was significantly more prevalent in those without <jats:italic>H.\u00a0pylori<\/jats:italic> infection, advanced\u2010stage disease, and in those with <jats:italic>API2\u2013MALT1<\/jats:italic> fusion. In overall analysis, those with CXCR3 expression showed a significantly increased risk of non\u2010responsiveness to <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy (odds ratio\u00a0=\u00a028.6; 95% confidence interval 5.70\u2013143.4) compared to those without CXCR3 expression. This higher risk was observed consistently regardless of sex, <jats:italic>API2\u2013MALT1<\/jats:italic> fusion, <jats:italic>H.\u00a0pylori<\/jats:italic> infection, or clinical stage. We showed that CXCR3 expression was an independent predictive factor for non\u2010responsiveness to <jats:italic>H.\u00a0pylori<\/jats:italic> eradication therapy in patients with gastric MALT lymphoma. (<jats:italic>Cancer Sci<\/jats:italic> 2008; 99: 1769\u20131773)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2008.00883.x","type":"journal-article","created":{"date-parts":[[2008,7,5]],"date-time":"2008-07-05T22:39:26Z","timestamp":1215297566000},"page":"1769-1773","source":"Crossref","is-referenced-by-count":13,"title":["Significance of CXCR3 expression in gastric low\u2010grade B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue type for predicting responsiveness to <i>Helicobacter pylori<\/i> 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