{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:50:23Z","timestamp":1767649823772},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,7,31]],"date-time":"2010-07-31T00:00:00Z","timestamp":1280534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>Stage IV marginal zone B\u2010cell lymphomas (MZL) are detected in more than 25% of lymphoma patients. In this study, we conducted retrospective analyses of specific cases of stage IV MZL in order to assess their clinical features, as well as the treatments and prognoses of these cases. A total of 94 patients with histological diagnosis of stage IV\u2010MZL from 17 different institutions in Korea were included. Multiple\u2010mucosa\u2010associated lymphoid tissue (MALT)\u2010organs\u2010involved MZL (M\u2010MZL) was detected in 34 patients (36.2%). Bone\u2010marrow\u2010involved stage IV MZL (BM\u2010MZL) was detected in 33 patients (35.1%). Median time to progression (TTP) was 2.4\u2003years (95% CI, 1.9\u20132.9). Five\u2010 and 10\u2010year overall survival rates were 84.5% and 79.8%, respectively. Patients with lymph node involvement in stage IV MZL appeared to have worse prognoses in TTP (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.015). Thirty\u2010one patients were treated with a regimen including rituximab (CTx\u2010R[+]), and 31 with a regimen that did not include rituximab (CTx\u2010R[\u2212]). The CTx\u2010R(+) group showed better responses than the CTx\u2010R(\u2212) group (83.9%<jats:italic>versus<\/jats:italic> 54.8%, <jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.026). However, no differences in TTP duration were detected (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.113). Stage IV MZL tend to follow an indolent disease course. Therefore, lymph node involvement is a more valuable prognostic factor for TTP. Rituximab appears to contribute to better responses, but not in cases of TTP. (<jats:italic>Cancer Sci<\/jats:italic> 2010; 101: 2443\u20132447)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2010.01698.x","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T12:07:28Z","timestamp":1282306048000},"page":"2443-2447","source":"Crossref","is-referenced-by-count":5,"title":["Stage IV marginal zone B\u2010cell lymphoma \u2013 prognostic factors and the role of rituximab: Consortium for Improving Survival of Lymphoma (CISL) study"],"prefix":"10.1111","volume":"101","author":[{"given":"Sung Yong","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Ho","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong\u2010Ho","family":"Won","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Gyu","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Il","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Soo","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deok\u2010Hwan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinny","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hye","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Sup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyeong\u2010Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeon Seok","family":"Eom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Yong","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheolwon","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo\u2010Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,7,31]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1279"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20874"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2004.08.003"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<806::AID-CNCR26>3.0.CO;2-V"},{"key":"e_1_2_8_6_2","first-page":"1860","article-title":"Report of the Committee on Hodgkin\u2019s Disease Staging Classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1630"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.3.802.003k19_802_806"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.0723"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190802510331"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.11-3-285"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.5376"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.09.131"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.011759"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2007.08.012"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11835"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25325"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.8.2486"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-009-0875-7"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3496"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24605"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.128"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.05.117"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.2010.01698.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.2010.01698.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T04:20:39Z","timestamp":1697430039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.2010.01698.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,31]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1349-7006.2010.01698.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.2010.01698.x","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,31]]}}}