{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:54:46Z","timestamp":1787014486017,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T00:00:00Z","timestamp":1297900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>\n                    Efficacy, immunogenicity and tolerability of the human papillomavirus (HPV)\u201016\/18 AS04\u2010adjuvanted vaccine were evaluated in Japanese women aged 20\u201325\u2003years, for which results have been reported previously. We analyzed the baseline data from that study and report the prevalence rates of HPV infection in young healthy Japanese women. One thousand and the forty Japanese women aged 20\u201325\u2003years were enrolled in a phase II, double\u2010blind, controlled, randomized, multicenter study. At study entry, cervical specimens were collected from the women and tested by line probe assay for 25 HPV\u2010types and by HPV\u201016\/18\u2010specific polymerase chain reaction. The most frequently detected HPV\u2010type in baseline cervical specimens was HPV\u201052 (8.1%), followed by HPV\u201016 (6.5%), HPV\u201051 (4.5%), HPV\u201018 (4.0%) and HPV\u201031 (3.8%). The proportion of HPV DNA\u2010positive women increased with severity of cytological abnormalities: 26.1% (237\/908) in normal cytology, 93.3% (70\/75) in low\u2010grade squamous intraepithelial lesion and 100% (7\/7) in high\u2010grade squamous intraepithelial lesion. The relative contribution of HPV\u201016 and HPV\u201018 was 4.1 and 3.0% for normal cytology cases, and 20.0 and 16.0% in low\u2010grade squamous intraepithelial lesion, respectively. HPV\u201016 was found in four of seven high\u2010grade squamous intraepithelial lesion cases (57.1%) and five of the six cervical intraepithelial neoplasia 2+ cases (83.3%). Multiple and single HPV infections were observed in 13.5% (140\/1039) and 20.7% (215\/1039) of all women, respectively. The HPV prevalence rates in Japanese women aged 20\u201325\u2003years underline the importance of HPV vaccination at a young age and this report should be useful for monitoring changes in HPV prevalence after widespread HPV vaccination in Japanese women. (\n                    <jats:italic>Cancer Sci<\/jats:italic>\n                    2011; 102: 877\u2013882)\n                  <\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.01878.x","type":"journal-article","created":{"date-parts":[[2011,1,19]],"date-time":"2011-01-19T12:46:57Z","timestamp":1295441217000},"page":"877-882","source":"Crossref","is-referenced-by-count":21,"title":["Prevalence and type distribution of human papillomavirus in healthy Japanese women aged 20 to 25\u2003years old enrolled in a clinical study"],"prefix":"10.1111","volume":"102","author":[{"given":"Ryo","family":"Konno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Dobbelaere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,2,17]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2165\/10898580-000000000-00000"},{"issue":"1","key":"e_1_2_8_5_2","first-page":"S1","article-title":"The epidemiology of genital human papillomavirus infection","volume":"24","author":"Trottier H","year":"2006","journal-title":"Vaccine"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021641"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22527"},{"key":"e_1_2_8_8_2","first-page":"C1","article-title":"HPV and Cervical Cancer in the World: 2007 report (Section I Continents and Regions)","volume":"25","author":"Castellsagu\u00e9 X","year":"2007","journal-title":"Vaccine"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.02.002"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2008.05.036"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.5.5.7211"},{"key":"e_1_2_8_12_2","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0140-6736(09)61567-1","article-title":"Sustained efficacy and immunogenicity of the human papillomavirus (HPV)\u201016\/18 AS04\u2010adjuvanted vaccine: analysis of a randomised placebo\u2010controlled trial up to 6.4\u2003years","volume":"374","author":"The GlaxoSmithKline Vaccine HPV\u2010007 Study Group","year":"2009","journal-title":"Lancet"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70101-7"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2006.04.068"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60946-5"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60852-6"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61248-4"},{"key":"e_1_2_8_18_2","unstructured":"OlssonS\u2010O PaavonenJ.Impact of HPV 6\/11\/16\/18 vaccine on abnormal Pap tests and procedures. 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