{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:35:11Z","timestamp":1791329711297,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Immunocompromised individuals, including those infected with human immunodeficiency virus (HIV), are at increased risk of Epstein\u2013Barr virus (EBV)\u2010associated aggressive B cell malignancies such as Burkitt\u2019s lymphoma (BL) or diffuse large B cell lymphoma (DLBCL). Differential diagnosis of these lymphomas requires histopathological, immunohistochemical and cytogenetic assessments. Rapid, less invasive approaches to the diagnosis of EBV\u2010associated B cell lymphomas are needed. Here, high\u2010throughput cytokine profiling of BL cell lines and EBV\u2010transformed B lymphoblastoid cell lines (B\u2010LCL), representing DLBCL, was carried out. By monitoring the production of 42 different cytokines, unique cytokine signatures were identified for BL and B\u2010LCL\/DLBCL. The BL cells produced interleukin (IL)\u201010, 10\u2003kDa interferon gamma\u2010induced protein (IP\u201010)\/CXCL10, macrophage\u2010derived chemokine (MDC)\/CCL22, macrophage inflammatory protein (MIP)\u20101\u03b1\/CCL3 and MIP\u20101\u03b2\/CCL4. In addition to these five cytokines, the cytokine signature of B\u2010LCL\/DLBCL cells included IL\u20108\/CXCL8, IL\u201013, platelet\u2010derived growth factor (PDGF)\u2010AA, and regulated upon activation, normal T cell expressed and secreted (RANTES)\/CCL5. Epstein\u2013Barr virus latency was responsible for the increased production of IL\u201010, MDC\/CCL22 and MIP\u20101\u03b1\/CCL3 in BL cells, suggesting that EBV\u2010mediated BL\u2010genesis involves these three cytokines. These results suggest that high\u2010throughput cytokine profiling might be a valuable tool for the differential diagnosis and might deepen our understanding of the pathogenesis of EBV\u2010associated B cell malignancies. (<jats:italic>Cancer Sci<\/jats:italic> 2011; 102: 1236\u20131241)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.01924.x","type":"journal-article","created":{"date-parts":[[2011,3,10]],"date-time":"2011-03-10T16:15:43Z","timestamp":1299773743000},"page":"1236-1241","source":"Crossref","is-referenced-by-count":42,"title":["Cytokine signatures of transformed B cells with distinct Epstein\u2013Barr virus latencies as a potential diagnostic tool for B cell 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