{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T06:22:19Z","timestamp":1771654939912,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T00:00:00Z","timestamp":1308787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>Mantle cell lymphoma (MCL) is recognized as a well\u2010defined B cell neoplasm characterized by overexpression of cyclin D1 (CCND1), with \u201cclassical\u201d and \u201caggressive\u201d variant subtypes. A small\u2010cell variant of MCL (small\u2010MCL), resembling small lymphocytic lymphoma\/chronic lymphocytic lymphoma (CLL\/SLL), has been added to the World Health Organization classification. However, to the best of our knowledge, there have been no studies focusing on this neoplasm. In the present study, we analyzed 15 cases of CCND1\u2010positive small\u2010MCL, including immunohistochemical analysis of Ki\u201067 and CCND1 expression, and compared our findings with those of 151 cases of classical MCL. Morphologically, most small\u2010MCL showed a diffuse growth pattern (76.9%), whereas others featured a very thin mantle zone pattern resembling a reactive follicle (23.1%). Bone marrow involvement and splenomegaly occurred significantly more frequently in small\u2010MCL than in classical MCL (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05). Ki\u201067 expression in small\u2010MCL was lower than in classical MCL (mean [\u00b12 SD] 12.5\u2003\u00b1\u200317.3% and 25.2\u2003\u00b1\u200325.5%, respectively; <jats:italic>P\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.001), but there was no significant difference in CCND1 expression (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.2445). The 5\u2010year survival rate in small\u2010MCL was 83.3%. Although there was no significant difference in outcome between small\u2010MCL and classical MCL (<jats:italic>P\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.287), only one small\u2010MCL patient died of the disease. Thus, small\u2010MCL constitutes a specific subset of indolent lymphoma with distinguishing features, possibly making a major contribution to the accuracy of therapeutic decisions. In addition, clinicians should be aware of the possible presence of small\u2010MCL to avoid making a misdiagnosis of follicular hyperplasia or CLL\/SLL. (<jats:italic>Cancer Sci<\/jats:italic> 2011; 102: 1734\u20131741)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.01988.x","type":"journal-article","created":{"date-parts":[[2011,5,25]],"date-time":"2011-05-25T10:49:30Z","timestamp":1306320570000},"page":"1734-1741","source":"Crossref","is-referenced-by-count":18,"title":["Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki\u201067 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