{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T04:30:47Z","timestamp":1719289847838},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>The insulin\u2010like growth factor (IGF) signaling system plays a central role in cellular growth, differentiation and proliferation. Although the association between <jats:italic>IGF1<\/jats:italic> gene polymorphisms and cancer risk has been evaluated for several carcinomas, this association has not yet been examined for stomach cancer. We investigated the association between <jats:italic>IGF1<\/jats:italic> polymorphisms and the risk of stomach cancer in a Japanese population. A total of 703 patients with stomach cancer and 1462 non\u2010cancer control subjects were enrolled in this case\u2013control study. Associations between polymorphisms of 10 <jats:italic>IGF1<\/jats:italic> loci and the risk of stomach cancer were evaluated using odds ratios (OR) and 95% confidence intervals (CI) in multiple logistic regression models. We observed that the C allele in rs1520220 and the G allele in rs4764887 were significantly associated with stomach cancer risk in the per\u2010allele model after adjusting for other risk factors (OR: 1.14 [95% CI: 1.00\u20131.30] and OR: 1.18 [95% CI: 1.02\u20101.36], respectively). We also observed a positive and dose\u2010dependent association between the number of risk alleles and stomach cancer risk (<jats:italic>P<\/jats:italic>\u2010trend: 0.019) when examining the two loci in the same model. These associations were still seen after adjusting for potential confounders, including sex, age, smoking status, history of diabetes and family history of stomach cancer. We did not find any significant interaction between these factors and the number of risk alleles. In conclusion, we observed a significant association between <jats:italic>IGF1<\/jats:italic> polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of <jats:italic>IGF1<\/jats:italic> is warranted. (<jats:italic>Cancer Sci<\/jats:italic> 2011; 102: 2231\u20132235)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.02062.x","type":"journal-article","created":{"date-parts":[[2011,8,20]],"date-time":"2011-08-20T11:36:11Z","timestamp":1313840171000},"page":"2231-2235","source":"Crossref","is-referenced-by-count":18,"title":["Association between insulin\u2010like growth factor\u20101 polymorphisms and stomach cancer risk in a Japanese 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