{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:55Z","timestamp":1791332935978,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,11,27]],"date-time":"2011-11-27T00:00:00Z","timestamp":1322352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:p>Adult T\u2010cell leukemia (ATL) is a fatal T\u2010cell malignancy associated with human T\u2010cell leukemia virus type I infection. The aberrant expression of nuclear factor\u2010\u03baB (NF\u2010\u03baB) is considered to contribute to the malignant phenotype and chemo\u2010resistance of ATL cells. Because of the poor prognosis of ATL, the development of new therapeutic strategies is direly needed. In the present study, we show that an I\u03baB kinase 2 (IKK2) inhibitor, IMD\u20100354, efficiently inhibits the survival of CD4<jats:sup>+<\/jats:sup>\u2003CD25<jats:sup>+<\/jats:sup>\u2003 primary ATL cells and prevents the growth of or induces apoptosis of patient\u2010derived ATL cell lines. Assays of transcription with integrated forms of reporter genes revealed that IMD\u20100354 suppresses NF\u2010\u03baB\u2010dependent transcriptional activity. Moreover, the daily administration of IMD\u20100354 prevents the growth of tumors in mice inoculated with ATL cells. Our results suggest that targeting IKK2 with a small molecule inhibitor, such as IMD\u20100354, is an attractive strategy for the treatment of ATL. (<jats:italic>Cancer Sci<\/jats:italic> 2012; 103: 100\u2013106)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.02110.x","type":"journal-article","created":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T23:46:01Z","timestamp":1317167161000},"page":"100-106","source":"Crossref","is-referenced-by-count":27,"title":["An I\u03baB kinase 2 inhibitor IMD\u20100354 suppresses the survival of adult T\u2010cell leukemia cells"],"prefix":"10.1111","volume":"103","author":[{"given":"Shin","family":"Uota","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md.","family":"Zahidunnabi Dewan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Saitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Itai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Yamaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,27]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2031"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.1989.tb02289.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90038-X"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91298-5"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92734-5"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208979"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.3.1071"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.11.4243.bloodjournal86114243"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910540411"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.14.5620"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.4.987"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065"},{"key":"e_1_2_7_16_2","first-page":"2360","article-title":"Constitutive activation of NF\u2010kappaB in primary adult T\u2010cell leukemia cells","volume":"93","author":"Mori N","year":"1999","journal-title":"Blood"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000109"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1588"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1593\/neo.03388"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0735"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.008"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2004.03.002"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-08-3247"},{"key":"e_1_2_7_25_2","first-page":"49","article-title":"Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells","volume":"55","author":"Ochiai T","year":"2008","journal-title":"J Med Dent Sci"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.10.010"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2010.03.001"},{"key":"e_1_2_7_28_2","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4049\/jimmunol.126.4.1393","article-title":"A monoclonal antibody (anti\u2010Tac) reactive with activated and functionally mature human T cells I. Production of anti\u2010Tac monoclonal antibody and distribution of Tac (+) cells","volume":"126","author":"Uchiyama T","year":"1981","journal-title":"J Immunol"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111992"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111379"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2221"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-010-0373-1"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208975"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21918"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2501"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn174"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3646"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-306571"}],"container-title":["Cancer Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1349-7006.2011.02110.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1349-7006.2011.02110.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T22:43:14Z","timestamp":1711233794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1349-7006.2011.02110.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,27]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["10.1111\/j.1349-7006.2011.02110.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1349-7006.2011.02110.x","archive":["Portico"],"relation":{},"ISSN":["1347-9032","1349-7006"],"issn-type":[{"value":"1347-9032","type":"print"},{"value":"1349-7006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,27]]}}}