{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T02:52:25Z","timestamp":1791168745140,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T00:00:00Z","timestamp":1326758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>\n                    Activation\u2010induced cytidine deaminase (AID\/AICDA) is required for somatic hypermutation and class\u2010switch recombination of the immunoglobulin gene, and for\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    translocation of germinal center\u2010derived B\u2010cell lymphoma. In the present study, we attempted to clarify the significance of\n                    <jats:italic>AID<\/jats:italic>\n                    associated with\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    in the progression of follicular lymphoma (FL) using RT\u2010PCR and quantitative real\u2010time PCR. Tissues from the patients with grade 3 FL expressed relatively higher levels of\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    and\n                    <jats:italic>AID<\/jats:italic>\n                    . The samples taken from a patient with FL who died within 2\u2003years after the start of treatment showed either no or low expression of\n                    <jats:italic>AID<\/jats:italic>\n                    , despite expressing high levels of\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    . In order to examine the role of AID expression in rapidly progressive FL, the full\u2010length\n                    <jats:italic>AID<\/jats:italic>\n                    transcript was transfected into\n                    <jats:italic>AID<\/jats:italic>\n                    \u2010negative cell lines established from different patients with rapidly progressive FL. This led to the establishment of\n                    <jats:italic>AID<\/jats:italic>\n                    \u2010expressing transfectants with a low proliferation rate and a significantly increased incidence of G\n                    <jats:sub>0<\/jats:sub>\n                    \/G\n                    <jats:sub>1<\/jats:sub>\n                    arrest compared with controls. Our results indicate that AID may act as a negative regulator of cell survival in FL when sufficient\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    is expressed. Switch\u2010off or low expression of\n                    <jats:italic>AID<\/jats:italic>\n                    after\n                    <jats:italic>c\u2010myc<\/jats:italic>\n                    amplification may correlate with the clinical outcomes of FL. (\n                    <jats:italic>Cancer Sci<\/jats:italic>\n                    2012; 103: 415\u2013421)\n                  <\/jats:p>","DOI":"10.1111\/j.1349-7006.2011.02186.x","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T02:22:54Z","timestamp":1323915774000},"page":"415-421","source":"Crossref","is-referenced-by-count":13,"title":["Role of activation\u2010induced cytidine deaminase in the progression of follicular 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