{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:15:25Z","timestamp":1791918925956,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,15]],"date-time":"2012-03-15T00:00:00Z","timestamp":1331769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Chronic lymphocytic leukemia (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>) is the most common leukemia in the western world. Alterations in micro<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s (mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>s) expression have been proposed to play a role in <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> pathogenesis. <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rosha are the main regulators of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> biogenesis, and deregulation of their expression has been indicated as a possible cause of mi<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> alterations observed in various cancers. To investigate the role of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rosha in <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>, we assessed the expression of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rosha and their correlation with other prognostic factors, including Binet stages, immunoglobulin heavy chain variable gene (<jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content>) mutation status, <jats:styled-content style=\"fixed-case\">TP<\/jats:styled-content>53 mutation status, <jats:styled-content style=\"fixed-case\">ZAP<\/jats:styled-content>\u201070 protein and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38 expression level in 165 <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> patients by using real\u2010time polymerase chain reaction methods. Patients with unmutated <jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content> genes had significantly lower expression of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer than patients with <jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content> mutations. The lower expression level of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer was also significantly associated with higher level of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38 and <jats:styled-content style=\"fixed-case\">ZAP<\/jats:styled-content>\u201070, and more aggressive <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>inet stage. We also analyzed <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer expression in different cytogenetic subgroups. Lower <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer level was found in patients with unfavorable cytogenetic aberrations (deletion in 17p13 or 11q22.3) in contrast to higher level in good risk cytogenetics (deletion in 13q14 as the sole abnormality). Furthermore, the lower expression of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer in <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> shows a strong association with shorter overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0046) as well as with reduced treatment free survival (<jats:styled-content style=\"fixed-case\">TFS<\/jats:styled-content>) (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0006). By contrast, no differences in the expression of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>rosha among these groups of patients were observed. Our data suggest that <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>icer expression may play an important role in the progression and prognosis of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>. (<jats:italic>Cancer Sci<\/jats:italic> 2012; 103: 875\u2013881)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2012.02234.x","type":"journal-article","created":{"date-parts":[[2012,2,9]],"date-time":"2012-02-09T15:41:01Z","timestamp":1328802061000},"page":"875-881","source":"Crossref","is-referenced-by-count":44,"title":["Downregulated <scp>D<\/scp>icer expression predicts poor prognosis in chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"103","author":[{"given":"Dan\u2010Xia","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Nanjing Medical University Jiangsu Province Hospital Nanjing 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