{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:52:14Z","timestamp":1791017534926,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,15]],"date-time":"2012-04-15T00:00:00Z","timestamp":1334448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>Previous reports have shown that circulating endothelial progenitor cells (<jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s) are released in response to cytotoxic chemotherapy. We investigate the relationship between the kinetics of <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s during one cycle of chemotherapy and the response to cytotoxic chemotherapy and prognostic impacts. Previously untreated patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) receiving cytotoxic chemotherapy for non\u2010small\u2010cell lung cancer were included. Blood sampling was carried out on day 1, day 8, and just before the second cycle of chemotherapy. The mononuclear cell fraction was analyzed for <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s by <jats:styled-content style=\"fixed-case\">FACS<\/jats:styled-content> analysis. We evaluated the relationship between the kinetics of <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s, each independent clinicopathological variable, the response to chemotherapy, and the risk factors associated with prognosis. On the eighth day after chemotherapy, a significant decrease in <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s was observed. In contrast, <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> counts before the second cycle of chemotherapy were significantly increased. The high percentage change in <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s between day 1 and before the second cycle of chemotherapy is an independent predictive factor for response to chemotherapy. However, the change in <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content> levels did not predict progression\u2010free survival. These findings indicate that the late release of <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s is a common phenomenon after chemotherapeutic treatment. The correlation with clinical response to chemotherapy provides further support for the biologic relevance of these cells in patients' prognosis and highlights the potential use of <jats:styled-content style=\"fixed-case\">CEP<\/jats:styled-content>s as therapeutic targets. (<jats:italic>Cancer Sci<\/jats:italic> 2012; 103: 1065\u20131070)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2012.02249.x","type":"journal-article","created":{"date-parts":[[2012,2,23]],"date-time":"2012-02-23T18:50:42Z","timestamp":1330023042000},"page":"1065-1070","source":"Crossref","is-referenced-by-count":17,"title":["Increase in circulating endothelial progenitor cells predicts response in patients with advanced non\u2010small\u2010cell lung cancer"],"prefix":"10.1111","volume":"103","author":[{"given":"Yuichi","family":"Sakamori","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Masago","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Graduate School of Medicine Kyoto University Kyoto 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