{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:25:03Z","timestamp":1790861103176,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T00:00:00Z","timestamp":1338768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p>Papillary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>) is a well\u2010differentiated endocrine malignant tumor that develops from thyroid follicular epithelium. The tumor represents the most common type of endocrine malignancy; however, its tumorigenesis is not fully elucidated. The aim of this study was to address the functional role of the sorting nexin (<jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>) family in <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> because of recent experimental evidence suggesting that the <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content> family members actively control endocytotic transportation as well as cell fate. Expression profiles of <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content> family members of <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> showed a significant quantity of transcripts of <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5. Further immunohistochemical analysis with an <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5\u2010specific monoclonal antibody established in this study consistently demonstrated the preferential expression of <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5 in <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content> (94.2%, 113\/120 cases) as indicated by studies on 440 cases of various tumors. In contrast, other major carcinomas originating from the lung (2.6%, 1\/38 cases), breast (5.1%, 2\/39 cases), and intestine (4.2%, 1\/24 cases) scarcely expressed <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5. When we investigated models of murine thyroid tumors induced by the administration of carcinogens, high expression of Snx5 was also observed in well\u2010differentiated thyroid tumors, further implying that the tumorigenesis of the thyroid gland was tightly associated with the abundance of <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5\/Snx5. Moreover epithelial cells expressing excess <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5 showed high levels of Caspase\u20102 of an initiator caspase. Collectively these findings suggest that the evaluation of <jats:styled-content style=\"fixed-case\">SNX<\/jats:styled-content>5 expression would support pathological diagnosis of primary and secondary <jats:styled-content style=\"fixed-case\">PTC<\/jats:styled-content>. (<jats:italic>Cancer Sci<\/jats:italic> 2012; 103: 1356\u20131362)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2012.02296.x","type":"journal-article","created":{"date-parts":[[2012,4,5]],"date-time":"2012-04-05T09:10:37Z","timestamp":1333617037000},"page":"1356-1362","source":"Crossref","is-referenced-by-count":17,"title":["Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase\u20102"],"prefix":"10.1111","volume":"103","author":[{"given":"Shihoko","family":"Ara","sequence":"first","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine Sapporo Japan"},{"name":"Department of Otolaryngology Sapporo Medical University School of Medicine Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University School of Medicine Sapporo 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