{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:21:07Z","timestamp":1790871667569,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,7,2]],"date-time":"2012-07-02T00:00:00Z","timestamp":1341187200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cancer Science"],"published-print":{"date-parts":[[2012,7]]},"abstract":"The aim of the current study was to evaluate the relation between xeroderma pigmentosum complementation group C (XPC<\/jats:styled-content><\/jats:italic>) polymorphisms and susceptibility to breast cancer (BC<\/jats:styled-content>), the development and progression of disease, and response to different individualized drug treatments. We investigated two polymorphisms in XPC<\/jats:styled-content> <\/jats:italic>A<\/jats:styled-content>la499V<\/jats:styled-content>al and L<\/jats:styled-content>ys939G<\/jats:styled-content>ln using PCR<\/jats:styled-content>\u2010RFLP<\/jats:styled-content> assays including 618 cases and 622 controls. The frequency of the TT<\/jats:styled-content> genotype of A<\/jats:styled-content>la499V<\/jats:styled-content>al (adjusted odds ratio\u00a0=\u00a01.575; 95% confidence interval, 1.104\u20132.245; P<\/jats:italic>\u00a0=\u00a00.012) and the AC<\/jats:styled-content> genotype of L<\/jats:styled-content>ys939G<\/jats:styled-content>ln (adjusted odds ratio\u00a0=\u00a01.330; 95% confidence interval, 1.045\u20131.694; P<\/jats:italic>\u00a0=\u00a00.020) were found to significantly increase the risk of developing BC<\/jats:styled-content>. The CT<\/jats:styled-content>+TT<\/jats:styled-content> genotypes of A<\/jats:styled-content>la499V<\/jats:styled-content>al were associated with estrogen receptor positive, and H<\/jats:styled-content>er\u20102 and p53 negative status, and the AC<\/jats:styled-content>+CC<\/jats:styled-content> genotypes of L<\/jats:styled-content>ys939G<\/jats:styled-content>ln were associated with BRCA<\/jats:styled-content>1 negative status. Moreover, a significantly increased chance of treatment with neoadjuvant anthracycline\u2010based chemotherapy response was found in women carrying TT<\/jats:styled-content> genotype of A<\/jats:styled-content>la499V<\/jats:styled-content>al, or CC<\/jats:styled-content> and AC<\/jats:styled-content> genotypes of L<\/jats:styled-content>ys939G<\/jats:styled-content>ln. In addition, a significantly longer overall survival after chemotherapy was observed in patients who had XPC<\/jats:styled-content> <\/jats:italic>L<\/jats:styled-content>ys939G<\/jats:styled-content>ln AC<\/jats:styled-content>+CC<\/jats:styled-content> genotypes with estrogen receptor positive (log\u2013rank test, P\u00a0<\/jats:italic>=\u00a00.086) and p53 negative (log\u2013rank test, P\u00a0<\/jats:italic>=\u00a00.020). The current data suggested that XPC<\/jats:styled-content> <\/jats:italic>A<\/jats:styled-content>la499V<\/jats:styled-content>al and L<\/jats:styled-content>ys939G<\/jats:styled-content>ln polymorphisms may contribute to the identification of patients with increased risk for BC<\/jats:styled-content>. Moreover, the polymorphisms were associated with the prognosis of BC<\/jats:styled-content> patients. (Cancer Sci<\/jats:italic> 2012; 103: 1207\u20131214)<\/jats:p>","DOI":"10.1111\/j.1349-7006.2012.02312.x","type":"journal-article","created":{"date-parts":[[2012,4,23]],"date-time":"2012-04-23T04:33:59Z","timestamp":1335155639000},"page":"1207-1214","source":"Crossref","is-referenced-by-count":9,"title":["Association of XPC<\/scp><\/i> polymorphisms with susceptibility and clinical outcome to chemotherapy in breast cancer patients"],"prefix":"10.1111","volume":"103","author":[{"given":"Xiuli","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacology School of Pharmaceutical Sciences China Medical University Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmaceutical Sciences China Medical University Shenyang 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