{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:37:35Z","timestamp":1790861855324,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,7,7]],"date-time":"2006-07-07T00:00:00Z","timestamp":1152230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> We reviewed all the publications concerning methadone\u2010associated Torsades de Pointes (TdP) (polymorphic ventricular tachycardia) in opioid\u2010dependent patients in order to characterize the clinical circumstances leading to this serious complication.<\/jats:p><jats:p><jats:bold>Methods\u2003<\/jats:bold> Our literature search yielded 14 reports on 40 patients with methadone\u2010associated TdP. We gathered and recorded the risk factors for TdP mentioned in those reports, among other clinical aspects.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> The most prevalent risk factors for TdP were high\u2010dose methadone (<jats:italic>n<\/jats:italic>\u2003=\u200339, 97.5%) and concomitant use of agents that increase serum methadone levels or trigger TdP (<jats:italic>n<\/jats:italic>\u2003=\u200322, 55%). HIV infection (<jats:italic>n<\/jats:italic>\u2003=\u200316), hypokalaemia (<jats:italic>n<\/jats:italic>\u2003=\u200314), female sex (<jats:italic>n<\/jats:italic>\u2003=\u200313), liver cirrhosis or renal failure (<jats:italic>n<\/jats:italic>\u2003=\u200311) and heart disease (<jats:italic>n<\/jats:italic>\u2003=\u20039) were also described. All the patients had at least one and 34 (85%) had two or more risk factors for TdP during methadone treatment.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> We wish to raise the level of awareness of risk factors for TdP among physicians in heroin\u2010treatment clinics who frequently prescribe methadone.<\/jats:p>","DOI":"10.1111\/j.1360-0443.2006.01512.x","type":"journal-article","created":{"date-parts":[[2006,7,8]],"date-time":"2006-07-08T01:28:14Z","timestamp":1152322094000},"page":"1333-1338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Methadone\u2010associated Torsades de Pointes (polymorphic ventricular tachycardia) in opioid\u2010dependent patients"],"prefix":"10.1111","volume":"101","author":[{"given":"Dan","family":"Justo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir","family":"Gal\u2010Oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Paran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Goldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zeltser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,8]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra032426"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.038240"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(83)80101-8"},{"key":"e_1_2_6_5_2","first-page":"135","volume-title":"Epidemiologic trends in drug abuse","author":"Van der Burgh C.","year":"1999"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.3.277"},{"key":"e_1_2_6_7_2","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).Annual report on the state of the drugs problems in the European Union. 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