{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:50:53Z","timestamp":1792900253793,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aim\u2003<\/jats:bold> To evaluate the impact of excessive alcohol consumption on the health\u2010related quality of life of patients receiving methadone treatment for opioid dependence.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> A cross\u2010sectional survey.<\/jats:p><jats:p><jats:bold>Participants\u2003<\/jats:bold> One hundred and ninety\u2010two patients attending out\u2010patient methadone clinics in the south\u2010east of England, United Kingdom.<\/jats:p><jats:p><jats:bold>Measurements\u2003<\/jats:bold> Quality of life (QoL) was assessed using the Medical Outcomes Study: General Health Survey, Short Form (SF\u201012). Alcohol consumption was assessed using the Alcohol Use Disorders Identification Test (AUDIT).<\/jats:p><jats:p><jats:bold>Findings\u2003<\/jats:bold> Approximately one\u2010third of the sample (57\/192) were AUDIT\u2010positive (score \u2265 8) and 20 of the 135 AUDIT\u2010negative patients reported past history of alcohol problems. AUDIT\u2010positive patients were less satisfied with their methadone dose than AUDIT\u2010negative patients (<jats:italic>P\u2003<\/jats:italic>=\u20030.002), despite having a higher dose. AUDIT\u2010positive patients reported more physical (<jats:italic>P\u2003<\/jats:italic>=\u20030.020) and psychological (<jats:italic>P\u2003<\/jats:italic>=\u20030.034) health problems and poorer QoL (<jats:italic>P\u2003<\/jats:italic>=\u20030.008) with an estimated effect size of 0.46. Lower QoL scores for AUDIT\u2010positive patients affected both \u2018physical\u2019 (<jats:italic>P\u2003<\/jats:italic>=\u20030.009) and \u2018psychological\u2019 (<jats:italic>P\u2003<\/jats:italic>=\u20030.012) health domains with poor role functioning (\u2018role limitation\u2019 due to physical health, <jats:italic>P<\/jats:italic> &lt;\u20030.001 and to emotional health, <jats:italic>P<\/jats:italic>\u2003=\u20030.009), social functioning (<jats:italic>P\u2003<\/jats:italic>=\u20030.015) and self\u2010perceived general health (<jats:italic>P\u2003<\/jats:italic>=\u20030.029).<\/jats:p><jats:p><jats:bold>Conclusion\u2003<\/jats:bold> Excessive alcohol consumption may be associated with a distinctive pattern of QoL impairment in methadone patients. In addition to advising methadone patients regarding their alcohol consumption, comprehensive care plans should seek to restore normal personal, family and social role functioning through the provision of appropriate health and social care.<\/jats:p>","DOI":"10.1111\/j.1360-0443.2006.01683.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T06:40:33Z","timestamp":1166078433000},"page":"257-263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Excessive alcohol consumption is associated with reduced quality of life among methadone patients"],"prefix":"10.1111","volume":"102","author":[{"given":"Richard","family":"Senbanjo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,13]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1080\/14659890215694"},{"key":"e_1_2_5_3_2","first-page":"60","article-title":"Managing the heavy drinker in Primary Care","volume":"8","author":"Drug and Therapeutic Bulletin.","year":"2000","journal-title":"Drug Ther Bull"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2002.00028.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/00952998509016848"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7130.542"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/16066359809004367"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(98)80011-4"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00352.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03405775"},{"key":"e_1_2_5_11_2","first-page":"211","article-title":"Life activities and life quality of heroin addicts in and out of methadone treatment","volume":"28","author":"Reno R. 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