{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T02:27:07Z","timestamp":1787711227465,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T00:00:00Z","timestamp":1284508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Aims\u2003<\/jats:bold> Detection of errors is crucial for efficient goal\u2010directed behaviour. The ability to monitor behaviour is found to be diminished in patients with substance dependence, as reflected in decreased error\u2010related brain activity, i.e. error\u2010related negativity (ERN). The ERN is also decreased in other psychiatric disorders with impaired response inhibition, such as attention\u2010deficit hyperactivity disorder and borderline personality disorder, but increased in anxiety disorders. The objective of the current study was to assess error monitoring in alcohol\u2010dependent patients in relation to psychiatric comorbidity. We expected decreased error monitoring in alcohol\u2010dependent patients with impulse control disorders and increased error monitoring in anxious alcohol\u2010dependent patients.<\/jats:p><jats:p><jats:bold>Design\u2003<\/jats:bold> In a case\u2013control design alcohol\u2010dependent patients were compared with healthy controls.<\/jats:p><jats:p><jats:bold>Setting and participants\u2003<\/jats:bold> A consecutive series of 29 male alcohol\u2010dependent patients, between 18 and 55 years of age, applying for in\u2010patient detoxification were recruited at Novadic Kentron Center for Addiction Treatment. Fifteen age\u2010matched healthy controls were recruited through advertisements in regional newspapers.<\/jats:p><jats:p><jats:bold>Measurements\u2003<\/jats:bold> Event\u2010related potentials were recorded while performing a speeded choice\u2010reaction task, from which ERN amplitudes were calculated. Axis\u2010I and \u2010II psychiatric comorbidity were assessed using the MINI International Neuropsychiatric Interview and the Structured Interview for DSM\u2010IV Personality disorders. All participants completed the Temperament and Character Inventory and Profile of Mood States.<\/jats:p><jats:p><jats:bold>Findings\u2003<\/jats:bold> ERN amplitudes were increased for alcohol\u2010dependent patients compared to healthy controls, particularly in patients with comorbid anxiety disorders.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Increased error monitoring in alcohol\u2010dependent patients, particularly those with comorbid anxiety disorders, is in contrast with previous studies that suggested decreased error monitoring to be a general feature in substance use disorders. Psychiatric disorders co\u2010occurring with alcohol dependence, such as anxiety disorders, may indicate subpopulations of alcohol\u2010dependent patients, with distinct neurobiological and genetic characteristics, possibly requiring different treatment strategies.<\/jats:p>","DOI":"10.1111\/j.1360-0443.2010.03065.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T09:41:37Z","timestamp":1284543697000},"page":"1928-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Alcohol dependence and anxiety increase error\u2010related brain activity"],"prefix":"10.1111","volume":"105","author":[{"given":"Arnt F. A.","family":"Schellekens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen R. A.","family":"De Bruijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa A. A.","family":"Van Lankveld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"Hulstijn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan K.","family":"Buitelaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor A. J.","family":"De Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robbert J.","family":"Verkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1100301"},{"key":"e_1_2_9_3_2","first-page":"192","volume-title":"Psychophysiological Brain Research","author":"Falkenstein M.","year":"1990"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.1993.tb00586.x"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.109.4.679"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.07.017"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2003.09.011"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2006.11.003"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301326"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076929"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.09.004"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2005.08.006"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.05.011"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2005.02.003"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.06.034"},{"key":"e_1_2_9_16_2","first-page":"77","article-title":"The error\u2010related negativity (ERN) and psychopathology: toward an endophenotype","volume":"64","author":"Olvet D. M.","year":"2008","journal-title":"Clin Psychol Rev"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/agn014"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-7358(99)00027-6"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1915-6"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.08.011"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001405"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30132"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300409"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.08.005"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh059"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1360-0443.2010.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1360-0443.2010.03065.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T15:36:34Z","timestamp":1698766594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1360-0443.2010.03065.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,15]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11]]}},"alternative-id":["10.1111\/j.1360-0443.2010.03065.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1360-0443.2010.03065.x","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,15]]},"assertion":[{"value":"2010-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}