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The relative risk (RR) of NAS was compared for methadone doses above versus below a range of cut\u2010off points. Summary RRs and 95% confidence intervals (CI) were estimated using random effects meta\u2010analysis. Sensitivity analyses explored the impact of limiting meta\u2010analyses to prospective studies or studies using an objective scoring system to diagnose NAS.<\/jats:p><jats:p><jats:bold>Results\u2003<\/jats:bold> A total of 67 studies met inclusion criteria for the systematic review; 29 were included in the meta\u2010analysis. Any differences in the incidence of NAS in infants of women on higher compared with lower doses were statistically non\u2010significant in analyses restricted to prospective studies or to those using an objective scoring system to diagnose NAS.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold> Severity of the neonatal abstinence syndrome does not appear to differ according to whether mothers are on high\u2010 or low\u2010dose methadone maintenance therapy.<\/jats:p>","DOI":"10.1111\/j.1360-0443.2010.03120.x","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T08:19:57Z","timestamp":1284538797000},"page":"2071-2084","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Methadone dose and neonatal abstinence syndrome\u2014systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"105","author":[{"given":"Brian J.","family":"Cleary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Strawbridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Fahey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"key":"e_1_2_7_2_2","unstructured":"Department of Health (England) and the Devolved Administrations.Drug Misuse and Dependence: UK Guidelines on Clinical Management. 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