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The dose of MDMA per pill ranged from 0 to 245\u2003mg and users consumed from one\u2010half to five pills, with the total dose consumed ranging up to 280\u2003mg. Plasma concentrations of MDMA increased with number of pills consumed and cumulative MDMA dose. Use of larger numbers of pills was associated with extended exposure to the drug.<\/jats:p><jats:p><jats:bold>Conclusions\u2003<\/jats:bold>MDMA is the major active drug in ecstasy pills, but there is a high degree of variation in doses. Use of multiple pills over the course of one session is common and results in a sustained increase in MDMA plasma concentrations over a number of hours. This is likely to lead to a much greater exposure of the brain to MDMA than would be predicted from controlled single\u2010dose pharmacokinetic studies.<\/jats:p>","DOI":"10.1111\/j.1360-0443.2011.03399.x","type":"journal-article","created":{"date-parts":[[2011,2,14]],"date-time":"2011-02-14T12:55:57Z","timestamp":1297688157000},"page":"1293-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Pill content, dose and resulting plasma concentrations of 3,4\u2010methylendioxymethamphetamine (MDMA) in recreational \u2018ecstasy\u2019 users"],"prefix":"10.1111","volume":"106","author":[{"given":"Kate 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