{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:46:05Z","timestamp":1792176365992,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T00:00:00Z","timestamp":1349395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n \n Opioid maintenance therapy (\n OMT<\/jats:styled-content>\n ) is generally recommended for pregnant opioid\u2010dependent women. Previous studies investigating the long\u2010term effects of\n OMT<\/jats:styled-content>\n on children's cognitive development found that children of women in\n OMT<\/jats:styled-content>\n have an increased risk of developing deficits in motor and visual perceptual skills, which are important aspects of the mirror neurone system (\n MNS<\/jats:styled-content>\n ), a complex neural circuit involved in learning and social interactions. The aim of the current study was to investigate aspects of the\n MNS<\/jats:styled-content>\n in children of women in\n OMT<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n A 2 (control group versus\n OMT<\/jats:styled-content>\n group)\u2009\u00d7\u20092 (human versus mechanic) mixed factorial design.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n The\n C<\/jats:styled-content>\n ognitive\n D<\/jats:styled-content>\n evelopmental\n R<\/jats:styled-content>\n esearch\n U<\/jats:styled-content>\n nit at the\n U<\/jats:styled-content>\n niversity of\n O<\/jats:styled-content>\n slo,\n N<\/jats:styled-content>\n orway.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Fifteen children of women in\n OMT<\/jats:styled-content>\n and 15 non\u2010exposed children participated.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Goal\u2010directed eye movements were recorded using a\n T<\/jats:styled-content>\n obii 1750 eye tracker. Neurocognitive tests were employed to map children's cognitive development.\n <\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n The\n OMT<\/jats:styled-content>\n group made fewer proactive goal\u2010directed eye movements [mean\u2009=\u2009\u221237.73, standard deviation (\n SD<\/jats:styled-content>\n )\u2009=\u2009208.56] compared to the control group (mean\u2009=\u2009181.47,\n SD<\/jats:styled-content>\n \u2009=\u2009228.65),\n F<\/jats:italic>\n (1,28)<\/jats:sub>\n \u2009=\u20097.53,\n P<\/jats:italic>\n \u2009=\u20090.01, \u03b7\n 2<\/jats:sup>\n \u2009=\u20090.21. No differences were found on tests of visual perception or goal understanding.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Use of opioid maintenance therapy during pregnancy appears to be associated with impaired goal\u2010directed eye movements in the 4\u2010year\u2010old infant which may affect later social adjustment adversely.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1360-0443.2012.04006.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T08:48:48Z","timestamp":1341564528000},"page":"154-160","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neurodevelopmental investigation of the mirror neurone system in children of women receiving opioid maintenance therapy during pregnancy"],"prefix":"10.1111","volume":"108","author":[{"given":"Carolien","family":"Konijnenberg","sequence":"first","affiliation":[{"name":"The Cognitive Developmental Research Unit Department of Psychology University of Oslo Oslo Norway"},{"name":"Norwegian Centre for Addiction Research University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Melinder","sequence":"additional","affiliation":[{"name":"The Cognitive Developmental Research Unit Department of Psychology University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,5]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Treatment CfSA.Medication\u2010assisted treatment for opioid addiction in opioid treatment programs.Treatment Improvement Protocol (TIP) Series 43.DHHS Publication no. 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Rockville MD: Substance Abuse and Mental Health Services Administration;2005."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95223910.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)00101-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.300.1.26"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1994.tb11809.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10826088609027399"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/15295190902844563"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2011.553591"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-005-0039-z"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2024"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cognition.2009.09.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnr.0000127464.17770.1f"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb21018.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-6383(84)80027-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb21017.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.27.070203.144230"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.169284"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210042"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1729"},{"key":"e_1_2_6_22_1","volume-title":"Nepsy: Neuropsykologisk Bed\u00f6mning 3: 10\u201312:11 \u00c5r [NEPSY: A developmental neuropsychological assessment]","author":"Korkman M.","year":"2000"},{"key":"e_1_2_6_23_1","volume-title":"Bender Visual\u2010Motor Gestalt Test","author":"Brannigan G. 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