{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:42:41Z","timestamp":1778805761915,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>To determine pre\u2010 and post\u2010dosing effects of prenatal methadone compared to buprenorphine on fetal wellbeing.<\/jats:p><\/jats:sec>Design<\/jats:title>A secondary analysis of data derived from the M<\/jats:styled-content>aternal O<\/jats:styled-content>pioid T<\/jats:styled-content>reatment: H<\/jats:styled-content>uman E<\/jats:styled-content>xperimental R<\/jats:styled-content>esearch (MOTHER<\/jats:styled-content>) study, a double\u2010blind, double\u2010dummy, randomized clinical trial.<\/jats:p><\/jats:sec>Setting<\/jats:title>Six U<\/jats:styled-content>nited S<\/jats:styled-content>tates sites and one E<\/jats:styled-content>uropean site that provided comprehensive opioid\u2010dependence treatment to pregnant women.<\/jats:p><\/jats:sec>Participants<\/jats:title>Eighty\u2010one of the 131 opioid\u2010dependent pregnant women completing the MOTHER<\/jats:styled-content> clinical trial, assessed between 31 and 33 weeks of gestation.<\/jats:p><\/jats:sec>Measurements<\/jats:title>Two fetal assessments were conducted, once before and once after study medication dosing. Measures included mean fetal heart rate (FHR<\/jats:styled-content>), number of FHR<\/jats:styled-content> accelerations, FHR<\/jats:styled-content> reactivity in the fetal non\u2010stress test (NST<\/jats:styled-content>) and biophysical profile (BPP<\/jats:styled-content>) score.<\/jats:p><\/jats:sec>Findings<\/jats:title>Significant group differences were found for number of FHR<\/jats:styled-content> accelerations, non\u2010reactive NST<\/jats:styled-content> and BPP<\/jats:styled-content> scores (all P<\/jats:styled-content><\/jats:italic>s\u2009<\u20090.05). There were no significant group differences before time of dosing. Significant decreases (all P<\/jats:styled-content><\/jats:italic>s\u2009<\u20090.05) occurred from pre\u2010 to post\u2010dose assessment for mean FHR<\/jats:styled-content>, FHR<\/jats:styled-content> accelerations, reactive NST<\/jats:styled-content> and fetal movement. The decrease in accelerations and reactive NST<\/jats:styled-content> were significant only for fetuses in the methadone group, and this resulted in a significantly lower likelihood of a reactive NST<\/jats:styled-content> compared to fetuses in the buprenorphine group.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Buprenorphine compared with methadone appears to result in less suppression of mean fetal heart rate, fetal heart rate reactivity and the biophysical profile score after medication dosing and these findings provide support for the relative safety of buprenorphine when fetal indices are considered as part of the complete risk\u2013benefit ratio.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1360-0443.2012.04037.x","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T16:30:49Z","timestamp":1351528249000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Fetal assessment before and after dosing with buprenorphine or methadone"],"prefix":"10.1111","volume":"107","author":[{"given":"Amy L.","family":"Salisbury","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Warren Alpert Medical School of Brown University Providence RI"},{"name":"Department of Psychiatry and Human Behavior The Warren Alpert Medical School of Brown University Providence RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara G.","family":"Coyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Warren Alpert Medical School of Brown University Providence RI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin E.","family":"O'Grady","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland College Park College Park MD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah 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