{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:57:41Z","timestamp":1790708261392,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the relationship of anxiety and depression symptoms with treatment outcomes (treatment discontinuation, rates of ongoing use of illicit drugs and likelihood of preterm delivery) in opioid\u2010dependent pregnant women and describe their use of psychotropic medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and setting<\/jats:title><jats:p>Secondary data analysis from a randomized clinical trial of treatment for opioid dependence during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 175 opioid\u2010dependent pregnant women, of whom 131 completed treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Symptoms of anxiety and depression were captured with the 15\u2010item Mini International Neuropsychiatric Interview (<jats:styled-content style=\"fixed-case\">MINI<\/jats:styled-content>) screen. Use of illicit drugs was measured by urine drug screening. Preterm delivery was defined as delivery prior to 37 weeks' gestation. Self\u2010reported use of concomitant psychotropic medication at any point during the study was recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>Women reporting only anxiety symptoms at study entry were more likely to discontinue treatment [adjusted odds ratio (<jats:styled-content style=\"fixed-case\">OR)<\/jats:styled-content>\u2009=\u20094.56, 95% confidence interval (<jats:styled-content style=\"fixed-case\">CI):<\/jats:styled-content>\u20091.91\u201313.26, <jats:italic>P<\/jats:italic>\u2009=\u20090.012], while those reporting only depression symptoms were less likely to discontinue treatment (adjusted <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20090.14, 95% <jats:styled-content style=\"fixed-case\">CI:<\/jats:styled-content>\u20090.20\u20130.88, <jats:italic>P<\/jats:italic>\u2009=\u20090.036) compared to women who reported neither depression nor anxiety symptoms. No statistically significant between\u2010group differences were observed for ongoing illicit drug use or preterm delivery. A majority (61.4%) of women reported use of concomitant psychotropic medication at some point during study participation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Opioid agonist\u2010treated pregnant patients with co\u2010occurring symptoms of anxiety require additional clinical resources to prevent premature discontinuation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1360-0443.2012.04041.x","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T16:30:49Z","timestamp":1351528249000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Opioid dependence during pregnancy: relationships of anxiety and depression symptoms to treatment outcomes"],"prefix":"10.1111","volume":"107","author":[{"given":"Margaret M.","family":"Benningfield","sequence":"first","affiliation":[{"name":"Department of Psychiatry Vanderbilt University  Nashville TN USA"},{"name":"Addiction Center Vanderbilt University  Nashville TN USA"},{"name":"Department of Pediatrics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vanderbilt University  Nashville TN USA"},{"name":"Department of Biostatistics Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendr\u00e9e E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology Johns Hopkins University  Baltimore MD USA"},{"name":"RTI International  Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Kaltenbach","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics, and Psychiatry and Human Behavior, Jefferson Medical College Thomas Jefferson University  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Heil","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Psychology University of Vermont  Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Stine","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Neurosciences Wayne State University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara G.","family":"Coyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Warren Alpert Medical School of Brown University  Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia M.","family":"Arria","sequence":"additional","affiliation":[{"name":"Center for Young Adult Health and Development University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin E.","family":"O'Grady","sequence":"additional","affiliation":[{"name":"Department of Psychology University of Maryland  College Park MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Addiction Clinic, and Center of Public Health Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vanderbilt University  Nashville TN USA"},{"name":"Addiction Center Vanderbilt University  Nashville TN USA"},{"name":"Department of Pharmacology Vanderbilt University  Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2007.10.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2010.00064.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2006.06.015"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1994.03950010008002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000116689.75396.5f"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02287700"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/00952999209001609"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.10.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05328gry"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990903108231"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2012.04036.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550490902772975"},{"key":"e_1_2_6_15_1","volume-title":"Structured clinical interview for DSM\u2014IV Axis I disorders","author":"First M. B.","year":"1996"},{"key":"e_1_2_6_16_1","first-page":"22","article-title":"The Mini\u2010International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM\u2010IV and ICD\u201010","volume":"59","author":"Sheehan D. V.","year":"1998","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/00048670601109949"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2007.01618.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0740-5472(92)90062-S"}],"container-title":["Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1360-0443.2012.04041.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1360-0443.2012.04041.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:47:38Z","timestamp":1694566058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1360-0443.2012.04041.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":18,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1360-0443.2012.04041.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1360-0443.2012.04041.x","archive":["Portico"],"relation":{},"ISSN":["0965-2140","1360-0443"],"issn-type":[{"value":"0965-2140","type":"print"},{"value":"1360-0443","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]},"assertion":[{"value":"2012-12-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}