{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:53:43Z","timestamp":1787014423789,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction"],"published-print":{"date-parts":[[2012,11]]},"abstract":"Abstract<\/jats:title>\n \n Aims<\/jats:title>\n To characterize infections and compare obstetric outcomes in opioid\u2010dependent pregnant women who participated in a randomized clinical trial comparing agonist medications, methadone and buprenorphine.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Incidence of infections was identified as part of the screening medical assessment. As part of a planned secondary analysis, analysis of variance and polytomous logistic regressions were conducted on obstetric outcome variables using treatment randomization condition (maternal maintenance with either methadone or buprenorphine) as the predictor variable, controlling for differences between study sites.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Six\n U<\/jats:styled-content>\n nited\n S<\/jats:styled-content>\n tates sites and one European site that provided comprehensive treatment to opioid\u2010dependent pregnant women.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Pregnant opioid\u2010dependent women (\n n<\/jats:italic>\n \u2009=\u2009131) who delivered while participating in the\n M<\/jats:styled-content>\n aternal\n O<\/jats:styled-content>\n pioid\n T<\/jats:styled-content>\n reatment:\n H<\/jats:styled-content>\n uman\n E<\/jats:styled-content>\n xperimental\n R<\/jats:styled-content>\n esearch (\n MOTHER<\/jats:styled-content>\n ) study.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Obstetric, infectious and other maternal medical complications captured by medical records, physical examination, blood tests and self\u2010report. Neonatal medical complications captured by medical records.<\/jats:p>\n <\/jats:sec>\n \n Findings<\/jats:title>\n \n Hepatitis\n C<\/jats:styled-content>\n was the most common infection (32.3%), followed by hepatitis\n B<\/jats:styled-content>\n (7.6%) and chlamydia (6.1%) among participants at study enrollment. Maternal methadone versus buprenorphine maintenance was associated with a higher incidence of preterm labor (\n P<\/jats:italic>\n \u2009=\u20090.04) and a significantly higher percentage of signs of respiratory distress in neonates at delivery (\n P<\/jats:italic>\n \u2009=\u20090.05). Other medical and obstetric complications were infrequent in the total sample, as well as in both methadone and buprenorphine conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Buprenorphine appears to have an acceptable safety profile for use during pregnancy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/j.1360-0443.2012.04042.x","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T12:30:49Z","timestamp":1351513849000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Infections and obstetric outcomes in opioid\u2010dependent pregnant women maintained on methadone or buprenorphine"],"prefix":"10.1111","volume":"107","author":[{"given":"Amber M.","family":"Holbrook","sequence":"first","affiliation":[{"name":"Department of Pediatrics Jefferson Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jefferson Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendr\u00e9e E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Behavioral Sciences and Obstetrics and Gynecology Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"RTI International Research Triangle Park NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Heil","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Vermont Burlington VT USA"},{"name":"Department of Psychology University of Vermont Burlington VT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara G.","family":"Coyle","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Warren Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Vanderbilt University Nashville TN USA"},{"name":"Department of Pharmacology Vanderbilt University Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Stine","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavior Neurosciences Wayne State University Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol","family":"Kaltenbach","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jefferson Medical College Thomas Jefferson University Philadelphia PA USA"},{"name":"Department of Psychiatry and Human Behavior Jefferson Medical College, Thomas Jefferson University Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v18n04_07"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1300\/J069v20n04_03"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.645"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200109000-00003"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90186-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-7-560"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/340827"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1971.00310200145021"},{"key":"e_1_2_6_10_1","first-page":"149","article-title":"Tetanus among injecting\u2010drug users\u2014California, 1997","volume":"47","author":"Centers for Disease Control and Prevention","year":"1998","journal-title":"Morb Mortal Wkly Rep"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80550-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/313703"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(69)90117-3"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-69-4-739"},{"key":"e_1_2_6_15_1","first-page":"1","article-title":"Pathophysiological and behavioual effects of the transplacental transfer of narcotic drugs to the fetuses and neonates of narcotic\u2010dependent mothers","volume":"31","author":"Finnegan L. 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