{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:33:35Z","timestamp":1768552415639,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica Scandinavica"],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> Local muscle metabolic responses to repetitive low\u2010force contractions and to intense static contractions were studied by microdialysis in humans.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Microdialysate and electromyography (EMG) were sampled from the trapezius muscle, mixed venous blood samples were taken and perceived exertion was rated (0\u20139) before and during 20\u2003min of standardized repetitive arm movement (REP), 60\u2003min recovery (R1), and 10\u2003min 90\u00b0 sustained arm position (SUS) at 20% maximum voluntary contraction, followed by 60\u2003min recovery (R2) in six healthy male participants (28\u201333\u2003years).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Average muscle activity was 8\u2003\u00b1\u20032% of EMG<jats:sub>max\u2212RMS<\/jats:sub> (mean\u2003\u00b1SEM) during REP and 22\u2003\u00b1\u20035% of EMG<jats:sub>max\u2212RMS<\/jats:sub> during SUS. Perceived exertion increased from 0 to 3.2\u2003\u00b1\u20030.5 during REP and from 0 to 8.5\u2003\u00b1\u20030.3 during SUS. During REP interstitial muscle lactate increased from 2.1\u2003\u00b1\u20030.2 to 2.9\u2003\u00b1\u20030.2\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and returned to the baseline level during R1, while dialysate [K<jats:sup>+<\/jats:sup>] increased from 3.8\u2003\u00b1\u20030.2 to 4.7\u2003\u00b1\u20030.2\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.002) and returned to 3.8\u2003\u00b1\u20030.2\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> during R1. In contrast, plasma lactate and [K<jats:sup>+<\/jats:sup>] remained unchanged. During SUS interstitial muscle lactate increased from 2.3\u2003\u00b1\u20030.2 to 3.3\u2003\u00b1\u20030.3\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.003), increased further to 6.5\u2003\u00b1\u20031.3\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> post\u2010exercise (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and returned to baseline levels during R2. Dialysate [K<jats:sup>+<\/jats:sup>] increased from 3.9\u2003\u00b1\u20030.2 to 4.6\u2003\u00b1\u20030.2\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup> (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and returned to baseline level during R2. Plasma lactate increased significantly during SUS whereas plasma [K<jats:sup>+<\/jats:sup>] was unchanged. During REP and SUS interstitial pyruvate was unchanged but increased in the post\u2010exercise period proportional to the exercise intensity.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> The microdialysis technique was effective in revealing muscle metabolic events that were not found systemically. Furthermore, the trapezius muscle showed an anaerobic metabolism during low\u2010force contraction, which could indicate inhomogeneous muscle activation.<\/jats:p>","DOI":"10.1111\/j.1365-201x.2004.01356.x","type":"journal-article","created":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T09:57:54Z","timestamp":1101722274000},"page":"379-388","source":"Crossref","is-referenced-by-count":67,"title":["Interstitial muscle lactate, pyruvate and potassium dynamics in the trapezius muscle during repetitive low\u2010force arm movements, measured with microdialysis"],"prefix":"10.1111","volume":"182","author":[{"given":"L.","family":"Rosendal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Blangsted","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"S\u00f8gaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Langberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sj\u00f8gaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kj\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,29]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awf029"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10249"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-35527"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1998.00429.x"},{"key":"e_1_2_19_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.4.E794"},{"key":"e_1_2_19_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0274(200011)38:5<516::AID-AJIM4>3.0.CO;2-0"},{"key":"e_1_2_19_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.1.460"},{"key":"e_1_2_19_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00849.x"},{"key":"e_1_2_19_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.3.E584"},{"key":"e_1_2_19_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00716.x"},{"key":"e_1_2_19_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1965.28.3.581"},{"key":"e_1_2_19_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1993.tb09490.x"},{"key":"e_1_2_19_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376465"},{"key":"e_1_2_19_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00864227"},{"key":"e_1_2_19_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.2.R400"},{"key":"e_1_2_19_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2002.00964.x"},{"key":"e_1_2_19_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00648.x"},{"key":"e_1_2_19_20_1","first-page":"E228","article-title":"A microdialysis method allowing characterization of intercellular water space in humans","volume":"253","author":"L\u00f6nnroth P.","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_19_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.281.4.H1734"},{"key":"e_1_2_19_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.4.1583"},{"key":"e_1_2_19_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.4.1483"},{"key":"e_1_2_19_24_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.3.R563"},{"key":"e_1_2_19_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90027-M"},{"key":"e_1_2_19_26_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.5.1810"},{"key":"e_1_2_19_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00161.x"},{"key":"e_1_2_19_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1998.274.5.E936"},{"key":"e_1_2_19_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(91)90114-F"},{"key":"e_1_2_19_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.4.1411"},{"key":"e_1_2_19_31_1","first-page":"21","article-title":"Muscle injury in repetitive motion disorders","volume":"351","author":"Sj\u00f8gaard G.","year":"1998","journal-title":"Clin Orthop"},{"key":"e_1_2_19_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004210000285"},{"key":"e_1_2_19_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.00641.x"},{"key":"e_1_2_19_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00269.x"},{"key":"e_1_2_19_35_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1985.53.5.1303"}],"container-title":["Acta Physiologica Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-201X.2004.01356.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-201X.2004.01356.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T09:07:07Z","timestamp":1697188027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-201X.2004.01356.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,29]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["10.1111\/j.1365-201X.2004.01356.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-201x.2004.01356.x","archive":["Portico"],"relation":{},"ISSN":["0001-6772","1365-201X"],"issn-type":[{"value":"0001-6772","type":"print"},{"value":"1365-201X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,29]]}}}