{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:25:50Z","timestamp":1773300350997,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T00:00:00Z","timestamp":1171324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Physiologica"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To determine the influence of inflammation on salivary secretion. Secretion by salivary glands involves interactions between nerves, blood vessels and salivary cells. The present study investigated the effects of inflammation on rat submandibular gland function following acute ductal obstruction.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Under recovery anaesthesia a metal clip was placed on the main duct of the submandibular gland. After 24\u2003h salivary secretion was evoked by nerve and methacholine stimulation. For recovery experiments the clip was removed after 24\u2003h and the animal left to recover for 3\u2003days when salivary function was again assessed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> By 24\u2003h of obstruction an inflammatory infiltrate had developed within the obstructed gland and stimulated salivary flows were just 20% of the normal secretion, whilst protein secretion and ion reabsorption were also severely impaired. If ductal obstruction was removed after 24\u2003h the salivary function returned to normal after 3\u2003days of recovery. <jats:italic>In vitro<\/jats:italic> analysis of cells from 24\u2010h ligated glands revealed normal changes in intracellular calcium (the main secondary messenger involved in fluid secretion) in response to methacholine stimulation. Protein secretion from isolated cells indicated some changes in particular to methacholine\u2010induced protein secretion although a significant protein secretion was still seen in response to isoprenaline \u2013 the main stimulus for protein secretion.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> This report demonstrates reversible salivary inhibition associated with an inflammatory infiltrate within the salivary gland.<\/jats:p>","DOI":"10.1111\/j.1365-201x.2006.01662.x","type":"journal-article","created":{"date-parts":[[2007,2,13]],"date-time":"2007-02-13T19:51:04Z","timestamp":1171396264000},"page":"241-249","source":"Crossref","is-referenced-by-count":38,"title":["Rat salivary gland ligation causes reversible secretory hypofunction"],"prefix":"10.1111","volume":"189","author":[{"given":"G. H.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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