{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:38:52Z","timestamp":1762864732432,"version":"build-2065373602"},"reference-count":44,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2004,3,15]],"date-time":"2004-03-15T00:00:00Z","timestamp":1079308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002The safety and efficacy of selective cyclo\u2010oxygenase\u20102 inhibitors in inflammatory bowel disease are under investigation.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To assess, in a prospective, open\u2010label trial, the efficacy and safety of rofecoxib (12.5\u2003mg\/day) in inflammatory bowel disease patients and controls.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002The inflammatory bowel disease group included 45 inactive patients (25 Crohn's disease; 20 ulcerative colitis) with associated arthralgia. The control group included 30 dyspeptic patients. The efficacy and safety of rofecoxib were assessed in inflammatory bowel disease patients and controls before and after treatment (range, 3\u2003days to 3\u2003months).<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002In inflammatory bowel disease, nine of the 45 patients (20%) required rofecoxib withdrawal due to gastrointestinal symptoms inducing clinical relapse, which subsided on drug discontinuation. The percentage of patients requiring rofecoxib discontinuation was comparable in patients with Crohn's disease and ulcerative colitis (20% vs. 20%), but was higher in inflammatory bowel disease patients than in controls (20% vs. 3%; <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). In inflammatory bowel disease, arthralgia relief was reported by 32 patients (71%): complete relief by eight patients (18%) and partial relief by 24 (53%). Thirteen patients (29%) reported no benefit. A comparable percentage of inflammatory bowel disease patients and controls reported arthralgia relief (71% vs. 70%).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Rofecoxib appears to control arthralgia in almost two\u2010thirds of inflammatory bowel disease patients. Side\u2010effects requiring drug discontinuation are observed, however, in almost one\u2010quarter of patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.01907.x","type":"journal-article","created":{"date-parts":[[2004,3,23]],"date-time":"2004-03-23T14:09:27Z","timestamp":1080050967000},"page":"755-764","source":"Crossref","is-referenced-by-count":33,"title":["Rofecoxib and early relapse of inflammatory bowel disease: an open\u2010label trial"],"prefix":"10.1111","volume":"19","author":[{"given":"L.","family":"Biancone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Tosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Geremia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Fina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Petruzziello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Emerenziani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pallone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,3,18]]},"reference":[{"key":"e_1_2_21_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00363-0"},{"key":"e_1_2_21_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)01207-9"},{"key":"e_1_2_21_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.16.s2.22.x"},{"key":"e_1_2_21_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-513"},{"key":"e_1_2_21_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02262.x"},{"key":"e_1_2_21_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.5.619"},{"key":"e_1_2_21_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.10268"},{"key":"e_1_2_21_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(98)00091-6"},{"volume-title":"Therapeutic Roles of Selective COX\u20102 Inhibitors","year":"2001","author":"Graham DY","key":"e_1_2_21_10_2"},{"issue":"16","key":"e_1_2_21_11_2","first-page":"6","article-title":"Gastrointestinal medications and procedures in osteoarthritis patients treated with rofecoxib compared with nonselective NSAIDs","volume":"3","author":"Watson DJ","year":"2001","journal-title":"Med Gen Med"},{"key":"e_1_2_21_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00900-4"},{"key":"e_1_2_21_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(76)80163-1"},{"key":"e_1_2_21_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172603"},{"key":"e_1_2_21_15_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50054"},{"key":"e_1_2_21_16_2","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti\u2010inflammatory drugs on the small and large intestine in humans","volume":"104","author":"Bjarnason I","year":"1983","journal-title":"Gastroenterology"},{"key":"e_1_2_21_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199209103271101"},{"key":"e_1_2_21_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.pm9041228"},{"key":"e_1_2_21_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)12031-2"},{"key":"e_1_2_21_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.suppl_3.iii25"},{"key":"e_1_2_21_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16510"},{"key":"e_1_2_21_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"key":"e_1_2_21_23_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.9561"},{"key":"e_1_2_21_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02263.x"},{"issue":"3","key":"e_1_2_21_25_2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1001\/archinte.1992.00400150135025","article-title":"Colitis induced by nonsteroidal anti\u2010inflammatory drugs. 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