{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:20:49Z","timestamp":1774794049906,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T00:00:00Z","timestamp":1091577600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002CagA protein is encoded by the <jats:italic>cag<\/jats:italic>A gene, which is part of the <jats:italic>cag<\/jats:italic> pathogenicity island (PAI) in <jats:italic>Helicobacter pylori<\/jats:italic>. Insertion sequence (IS) elements are a diverse set of specialized DNA segments that can move to new sites in bacterial genomes.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To determine the role of <jats:italic>cag<\/jats:italic>PAI and IS<jats:italic>605<\/jats:italic> in the development of gastric cancer, we analysed <jats:italic>cag<\/jats:italic>PAI from patients with gastric cancer and compared the results with the host's CagA antibody status.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002<jats:italic>H. pylori<\/jats:italic> strains were isolated from 29 gastric cancer patients, and CagA status was determined by measuring serum antibody against CagA. The <jats:italic>cag<\/jats:italic>PAI region and IS<jats:italic>605<\/jats:italic> were determined by PCR.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002CagA seropositivity tended to be higher in the IS<jats:italic>605<\/jats:italic>\/PAI<jats:sup>+<\/jats:sup> group (5\/7, 71.4%) than in the IS<jats:italic>605<\/jats:italic>\/PAI<jats:sup>\u2013<\/jats:sup> group (9\/22, 40.9%). Association with <jats:italic>cag13<\/jats:italic> was more frequent in the IS<jats:italic>605<\/jats:italic><jats:sup>+<\/jats:sup> group (92.3%; 12\/13) than in the IS<jats:italic>605<\/jats:italic><jats:sup>\u2013<\/jats:sup> group (25.0%; 4\/16; <jats:italic>P<\/jats:italic>\u2003=\u20030.0005).<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002<jats:italic>cag<\/jats:italic>13 may be associated with the presence of IS<jats:italic>605<\/jats:italic> in gastric cancer patients.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.01982.x","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T10:07:02Z","timestamp":1103450822000},"page":"13-16","source":"Crossref","is-referenced-by-count":6,"title":["Analysis of the cag pathogenicity island and IS605 of <i>Helicobacter pylori<\/i> strains isolated from patients with gastric cancer in Japan"],"prefix":"10.1111","volume":"20","author":[{"given":"R.","family":"Deguchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,4]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"188","volume-title":"IARC Monograph: Evaluation of Carcinogenic Risks in Humans.","year":"1994"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(200002)9999:9999<::AID-IJC1088>3.0.CO;2-B"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.3.336"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2001.tb01551.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70281-7"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.3.297"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01253.x"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750305431"},{"key":"e_1_2_12_10_2","first-page":"648","article-title":"Relation between infection of CagA\u2010positive Helicobacter pylori and upper gastrointestinal diseases","volume":"81","author":"Yang G","year":"2001","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018846723379"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.3.1625-1629.2001"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.52.9.653"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.4.593"},{"key":"e_1_2_12_15_2","doi-asserted-by":"crossref","first-page":"14559","DOI":"10.1073\/pnas.96.25.14559","article-title":"Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori","volume":"96","author":"Segal ED","year":"1999","journal-title":"Proc Natl Acad Sci"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.01982.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.01982.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2004.01982.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:11:20Z","timestamp":1695813080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2004.01982.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":14,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1365-2036.2004.01982.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2004.01982.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}