{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:02:03Z","timestamp":1770282123609,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"s1","license":[{"start":{"date-parts":[[2004,8,4]],"date-time":"2004-08-04T00:00:00Z","timestamp":1091577600000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Gastric cancer incidence in men is almost double that in women. We investigated mucosal responses in the stomach against <jats:italic>Helicobacter pylori<\/jats:italic> (<jats:italic>H. pylori<\/jats:italic>) infections to elucidate the interindividual or sex\u2010related differences, which may in turn be associated with gastric cancer incidence, mucosal changes of stomach as measured by the Sydney System, and interleukin\u20108, cyclooxygenase\u20102 and trefoil factor family 1 (TFF1) gene expression.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002An age\u2010, sex\u2010, <jats:italic>H. pylori<\/jats:italic> status\u2010 and disease\u2010matched case\u2212control study was performed in 574 <jats:italic>H. pylori<\/jats:italic>\u2010positive and 225 <jats:italic>H. pylori<\/jats:italic>\u2010negative patients selected from 4125 patients with a diagnosis of benign disease of the stomach. Levels of acute and chronic inflammations, atrophy and intestinal metaplasia scored according to the Sydney System were compared by stomach site and by sex. Two biopsy specimens (antral and corpus gastric mucosa) from patients with benign gastric diseases (142 patients; 72 men, 70 women) were analysed for interleukin\u20108, cyclooxygenase\u20102 and TFF1 mRNA expression as measured by real\u2010time PCR.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Inflammation and activity scores in antrum with <jats:italic>H. pylori<\/jats:italic> infection were higher in men, but scores declined according to age. Atrophy and intestinal metaplasia scores in corpus with <jats:italic>H. pylori<\/jats:italic> infection appeared more severe in men than in women, especially in older patients. In women, atrophy score increased with increasing age, particularly in postmenopausal <jats:italic>H. pylori<\/jats:italic>\u2010negative patients. Interleukin\u20108 mRNA induction was detected in both antrum and corpus mucosa in <jats:italic>H. pylori<\/jats:italic> infection, but sex differences were not found. Response of cyclooxygenase\u20102 mRNA expression against <jats:italic>H. pylori<\/jats:italic> infection in the mucosa was higher in men than women. In <jats:italic>H. pylori<\/jats:italic>\u2010negative patients, TFF1 mRNA levels in women were significantly higher than in men, and TFF1 mRNA was significantly lower in positive than negative women.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002Sex differences in mucosal responses to <jats:italic>H. pylori<\/jats:italic> infection in the stomach may be correlated with sex differences in the incidence of stomach cancer.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.01985.x","type":"journal-article","created":{"date-parts":[[2004,12,19]],"date-time":"2004-12-19T10:07:02Z","timestamp":1103450822000},"page":"17-24","source":"Crossref","is-referenced-by-count":29,"title":["Sex differences in mucosal response to <i>Helicobacter pylori<\/i> infection in the stomach and variations in interleukin\u20108, COX\u20102 and trefoil factor family 1 gene expression"],"prefix":"10.1111","volume":"20","author":[{"given":"S.","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Matsukura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Togashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Naito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Matsuhisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Tajiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,4]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"1","volume-title":"No. 41, Tokyo: Japan","author":"Kuroishi T","year":"1994"},{"key":"e_1_2_12_3_2","first-page":"167","volume-title":"Cancer Mortality in 33 Countries of the World (1953\u201387). Cancer Mortality and Morbidity Statistics: Japan and the World, 1994.","author":"Kuroishi T","year":"1994"},{"key":"e_1_2_12_4_2","volume-title":"Cancer in Five Continents, 1992, VI.","author":"Parkin DM","year":"1992"},{"key":"e_1_2_12_5_2","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risks to Humans of Infection with Helicobacter pylori.Schistosomes liver flukes andHelicobacter pylori.IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Vol.61. Lyon:International Agency for Research on Cancer 1994;177\u2013240."},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199610000-00001"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa001999"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.10.967"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114922"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.6.782"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1993.265.2.G205"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5285.259"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1218"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2003.00121.x"},{"key":"e_1_2_12_15_2","first-page":"709","article-title":"Use of a novel real\u2010time quantitative reverse transcription\u2010polymerase chain reaction method to study the effects of cytokines on cytochrome p450 mRNA expression in mouse liver","volume":"28","author":"Pan J","year":"2000","journal-title":"Am J Pharmacol Exp Therapeutics"},{"key":"e_1_2_12_16_2","first-page":"781","article-title":"Measurement of cytochrome p450 gene induction in human hepatocytes using quantitative real\u2010time reverse transcriptase\u2010polymerase chain reaction","volume":"28","author":"Bowen WP","year":"2000","journal-title":"Am J Pharmacol Exp Therapeutics"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200200037"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101200200036"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.6.890"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711710406"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00679.x"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.44.28560"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.01985.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.01985.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2004.01985.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:11:47Z","timestamp":1695813107000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2004.01985.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":21,"journal-issue":{"issue":"s1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["10.1111\/j.1365-2036.2004.01985.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2004.01985.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}