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The operation is technically complex and takes a long time to learn. Inexperience of the individual surgeon is a major factor contributing to the occurrence of postsurgical complications. Fundoplication does not prevent the occurrence of Barrett's oesophagus nor its progression to oesophageal adenocarcinoma. There is no evidence to suggest that the procedure is less costly or more cost\u2010effective than long\u2010term maintenance therapy with antisecretory medications, especially if surgical failures and postsurgical complications are taken into account. Fundoplication represents an alternative to medical therapy in patients with gastro\u2010oesophageal reflux disease who cannot or do not want to be on long\u2010term maintenance therapy with antisecretory medication. Endoluminal procedures, such as radiofrequency ablation, endoscopic suturing and injection at the gastro\u2010oesophageal junction, work only in mild forms of reflux disease. They fail to provide complete relief of reflux symptoms and do not heal erosive oesophagitis. All endoluminal procedures would have to undergo major technological improvements before they could become comparable with fundoplication or antisecretory therapy.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.02130.x","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T08:49:09Z","timestamp":1096447749000},"page":"81-88","source":"Crossref","is-referenced-by-count":5,"title":["Review article: anti\u2010reflux surgery and endoluminal therapies"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Sonnenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,29]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1177\/000313480006600302","article-title":"Heartburn is more likely to recur after Toupet fundoplication than Nissen fundoplication","volume":"66","author":"Farrell TM","year":"2000","journal-title":"Am Surg"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.4.468"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00049-X"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004640000043"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900534"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203193261202"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.18.2331"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241598750005381"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00797-3"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.8.1015"},{"key":"e_1_2_14_12_2","first-page":"6803","article-title":"Influence of esophagojejunostomy on the induction of adenocarcinoma of the distal esophagus in Sprague\u2010Dawley rats by subcutaneous injection of 2,6\u2010dimethyl\u2010nitrosomorpholine","volume":"49","author":"Pera M","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(98)80021-8"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29587"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(99)00260-9"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29569"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.4065\/76.3.335"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.08702.x"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02173.x"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01146.x"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.01297.x"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00019509-199702000-00005"},{"key":"e_1_2_14_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199910000-00015"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.4.487"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529950172943"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(98)00993-X"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000190070"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(99)00261-0"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.4.488"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70118-5"},{"key":"e_1_2_14_31_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.112843"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2002.121227"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)01052-7"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.113502"},{"key":"e_1_2_14_35_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.113912"}],"container-title":["Alimentary Pharmacology &amp; 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