{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:45:52Z","timestamp":1761630352447,"version":"3.30.2"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T00:00:00Z","timestamp":1092787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold>:\u2002The attenuated anti\u2010secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether<jats:italic>Helicobacter pylori<\/jats:italic>infection affects the occurrence of tolerance to H2RA. It is also not clarified whether the tolerance phenomenon occurs to a new H2RA, lafutidine.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold>:\u2002To investigate the occurrence of the tolerance phenomenon in subjects with and without<jats:italic>H. pylori<\/jats:italic>infection during the continuous administration of lafutidine and famotidine.<\/jats:p><jats:p><jats:bold>Subjects and Methods<\/jats:bold>:\u2002Subjects were 20 healthy male volunteers (seven<jats:italic>H. pylori<\/jats:italic>positive and 13<jats:italic>H. pylori<\/jats:italic>negative cases). All subjects were examined by ambulatory intragastric pH monitoring five times without medication, on the first and 15th day of the administration of 20\u2003mg b.d. famotidine and 10\u2003mg b.d. lafutidine in a cross\u2010over fashion.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold>:\u2002The tolerance phenomenon was not observed in<jats:italic>H. pylori<\/jats:italic>\u2010positive subjects during the 15\u2010day\u2010long administration of both H2RAs. In contrast, the tolerance phenomenon was observed in<jats:italic>H. pylori<\/jats:italic>negative subjects, which has been previously reported.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold>:\u2002This study demonstrated that<jats:italic>H. pylori<\/jats:italic>infection affects the tolerance phenomenon during continuous administration of H2RAs.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.02147.x","type":"journal-article","created":{"date-parts":[[2004,8,31]],"date-time":"2004-08-31T14:38:16Z","timestamp":1093963096000},"page":"559-565","source":"Crossref","is-referenced-by-count":21,"title":["<i>Helicobacter pylori<\/i>infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists"],"prefix":"10.1111","volume":"20","author":[{"given":"T.","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Adachi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Komazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Azumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Katsube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Kazumori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,8,18]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00656.x"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1994.tb00278.x"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.03041.x"},{"issue":"1","key":"e_1_2_10_5_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2036.1990.tb00009.x","article-title":"Loss of acid suppression during dosing with H2\u2010receptor antagonists","volume":"4","author":"Wilder\u2010Smith C","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"e_1_2_10_6_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1365-2036.1990.tb00011.x","article-title":"Tolerance during 8\u2003days of high\u2010dose H2\u2010blockade: placebo\u2010controlled studies of 24\u2010hour acidity and gastrin","volume":"4","author":"Smith JT","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"e_1_2_10_7_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1365-2036.1990.tb00010.x","article-title":"Tolerance during 29\u2003days of conventional dosing with cimetidine, nizatidine, famotidine or ranitidine","volume":"4","author":"Nwokolo CU","year":"1990","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.40.1.36"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.857_y.x"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(94)94341-9"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.00257.x"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01701.x"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1999.00656.x"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2002.02785.x"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050372"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01593.x"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007801"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365528909091254"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1991.tb00017.x"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1991.tb00019.x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409105360"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00791.x"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2001.01022.x"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02922.x"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1130060503"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.379"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214869"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02090359"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0190"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(91)90644-Z"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)80010-8"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.452"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.3.330"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.68.161"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2003.12"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00019-0"},{"key":"e_1_2_10_37_2","first-page":"828","article-title":"Lafutidine, a novel histamine H2 receptor antagonist, inhibits daytime acid secretion in both H. pylori infected and non\u2010infected human subjects","volume":"17","author":"Saitoh T","year":"2002","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02147.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02147.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2004.02147.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T13:00:48Z","timestamp":1734526848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2004.02147.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8,18]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["10.1111\/j.1365-2036.2004.02147.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2004.02147.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"type":"print","value":"0269-2813"},{"type":"electronic","value":"1365-2036"}],"subject":[],"published":{"date-parts":[[2004,8,18]]}}}