{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:17:03Z","timestamp":1792880223334,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T00:00:00Z","timestamp":1098316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Gastro\u2010oesophageal reflux disease is a common entity. Erosive oesophagitis, ulcers and Barrett's oesophagus, which is found in up to 10% of gastro\u2010oesophageal reflux disease patients, characterize severe gastro\u2010oesophageal reflux disease. Patients with Barrett's oesophagus have 0.5% per patient\u2010year risk of developing oesophageal adenocarcinoma. Currently, it appears that a minority of those at risk for Barrett's oesophagus undergo screening in part because of the costs associated with endoscopy as well as risks of sedation. A new ingestible PillCam oesophageal capsule developed may offer an alternative office\u2010based approach to visualize the oesophagus without sedation.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To compare the oesophageal capsule to conventional upper endoscopy for detection of oesophageal pathologies.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002A newly developed capsule, which acquires video images from both ends of the device at a 4\u2003frame\/s rate, was ingested by 17 fasting patients with suspected oesophageal disorders. An ingestion procedure aimed to lengthen capsule transit time in the oesophagus was utilized. Subsequently, a standard upper endoscopy was carried out. The investigator interpreting the capsule findings was blinded to the endoscopy results and vice versa. Patients with dysphagia, known Zenker's diverticulum, intestinal obstruction, cardiac pacemaker or pregnancy were excluded.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Twelve of the 17 patients examined had oesophageal findings using the endoscope as the gold standard. Capsule endoscopy identified oesophageal pathology in all 12 of these patients and an additional pathology in one patient that was missed during endoscopy. For the purpose of this study, this finding was regarded as a false\u2010positive. The mean oesophageal passage time was 189\u2003\u00b1\u2003280\u2003s. The positive predictive value of the oesophageal capsule for any oesophageal pathology was 92% and the negative predictive value was 100%. Oesophageal capsule sensitivity was 100% and specificity 80%. There were neither swallowing difficulties nor complications subsequent to ingestion in any subjects. Seventy\u2010three percentage of patients preferred the oesophageal capsule procedure on conventional endoscopy. Only one patient preferred oesophagogastroduodenoscopy.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002This pilot study has shown that oesophageal capsule endoscopy is an accurate, convenient, safe and well\u2010tolerated method to screen patients for significant oesophageal disorders. No sedation is required, which may allow simple, office\u2010based screening and assessment. Further, large\u2010scale studies are necessary to more fully assess this novel diagnostic tool.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.02206.x","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T04:17:50Z","timestamp":1110428270000},"page":"1083-1089","source":"Crossref","is-referenced-by-count":120,"title":["A novel diagnostic tool for detecting oesophageal pathology: the PillCam oesophageal video capsule"],"prefix":"10.1111","volume":"20","author":[{"given":"R.","family":"Eliakim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Shlomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Suissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. M.","family":"Eisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,11,3]]},"reference":[{"issue":"1","key":"e_1_2_12_2_2","first-page":"S5","article-title":"Reflux disease: the disorder of the third millennium","volume":"13","author":"Holtmann G.","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_12_4_2","first-page":"81","article-title":"Clinical epidemiology and natural history of gastroesophageal reflux disease","volume":"72","author":"Sonnenberg A","year":"1999","journal-title":"Yale J Biol Med"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05910.x"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.2165\/00019053-200119100-00003"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.15.1972"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00406.x"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70280-5"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70003-9"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70037-0"},{"key":"e_1_2_12_12_2","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3748\/wjg.v10.i9.1238","article-title":"Wireless capsule video endoscopy: three years of experience","volume":"10","author":"Eliakim R.","year":"2004","journal-title":"World J Gastroenterol"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43488"},{"key":"e_1_2_12_14_2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/j.1572-0241.1999.990_m.x","article-title":"Does this patient have Barrett's esophagus? The utility of predicting Barrett's esophagus at the index endoscopy","volume":"94","author":"Eloubeidi MA","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-3-200302040-00009"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02714-7"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02206.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02206.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2004.02206.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:22:06Z","timestamp":1697239326000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2004.02206.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1365-2036.2004.02206.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2004.02206.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}