{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:26:26Z","timestamp":1748823986329},"reference-count":17,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,10,21]],"date-time":"2004-10-21T00:00:00Z","timestamp":1098316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Lacking an objective \u2018gold standard\u2019 for diagnosing dyspepsia, several symptom\u2010based classifications have been suggested.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To assess if response to proton\u2010pump inhibitor treatment could provide useful information for current or future dyspepsia classification.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002<jats:italic>Post hoc<\/jats:italic> analyses of 829 patients treated with omeprazole or placebo in a randomized\u2010controlled trial. The \u2018true\u2019 response to omeprazole (trial response minus placebo response) was assessed according to different classifications of dyspepsia and different symptoms.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Symptoms described with the words \u2018burning\u2019 or \u2018sour\u2019 and patients with reflux\u2010like dyspepsia demonstrated high response to omeprazole treatment, whereas patients with abdominal pain or ulcer\u2010like dyspepsia responded unpredictably to omeprazole. The response to omeprazole in patients with epigastic pain was related to the pattern of other dyspeptic symptoms. Patients with heartburn or regurgitation overlapped extensively with patients with epigastric pain.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002The study demonstrated significant problems in the current classification of dyspepsia: \u2018the most bothersome symptom\u2019 was not independently related to the omeprazole effect and, in patients with abdominal pain, the response to omeprazole was dependent on the presence or absence of other dyspeptic symptoms. The overlap of symptoms indicates that heartburn and regurgitation should be recognized as symptoms of dyspepsia in primary care.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.02243.x","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T04:17:50Z","timestamp":1110428270000},"page":"1171-1179","source":"Crossref","is-referenced-by-count":13,"title":["Classification of dyspepsia and response to treatment with proton\u2010pump inhibitors"],"prefix":"10.1111","volume":"20","author":[{"given":"V.","family":"Meineche\u2010Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,3]]},"reference":[{"key":"e_1_2_19_2_2","first-page":"576","article-title":"Management of dyspepsia: report of a working party","author":"Colin\u2010Jones DG","year":"1988","journal-title":"Lancet"},{"key":"e_1_2_19_3_2","first-page":"145","article-title":"Functional dyspepsia: a classification with guidelines for diagnosis and management","volume":"4","author":"Talley NJ","year":"1991","journal-title":"Gastroenterol Int"},{"key":"e_1_2_19_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii37"},{"key":"e_1_2_19_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92023-0"},{"key":"e_1_2_19_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01706.x"},{"key":"e_1_2_19_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/17.6.514"},{"key":"e_1_2_19_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171431"},{"key":"e_1_2_19_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/028134398750002981"},{"key":"e_1_2_19_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/13814789709160347"},{"key":"e_1_2_19_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30089.x"},{"key":"e_1_2_19_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-9458-5"},{"key":"e_1_2_19_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489234"},{"key":"e_1_2_19_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00489237"},{"key":"e_1_2_19_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00866.x"},{"key":"e_1_2_19_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00282.x"},{"key":"e_1_2_19_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.0284f.x"},{"key":"e_1_2_19_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30488.x"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02243.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2004.02243.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2004.02243.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T23:22:22Z","timestamp":1697239342000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2004.02243.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["10.1111\/j.1365-2036.2004.02243.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2004.02243.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}