{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:43:15Z","timestamp":1762504995796},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2004,11,29]],"date-time":"2004-11-29T00:00:00Z","timestamp":1101686400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Although administration of gastroprotective drugs may reduce the risk of peptic ulcers associated with the chronic use of non\u2010steroidal anti\u2010inflammatory drugs or aspirin, no consensus exists as to whether this co\u2010therapy is effective for short\u2010term prevention, particularly in old age.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To evaluate the risk of peptic ulcer associated with acute and chronic non\u2010steroidal anti\u2010inflammatory drugs or aspirin therapy in elderly subjects, and the influence of antisecretory treatment on this risk.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002The study included 676 elderly non\u2010steroidal anti\u2010inflammatory drugs or aspirin users and 2435 non\u2010users who consecutively underwent upper gastrointestinal endoscopy. The use of non\u2010steroidal anti\u2010inflammatory drugs and\/or aspirin as well as antisecretory drugs (H<jats:sub>2<\/jats:sub>\u2010blockers and proton\u2010pump inhibitors) was evaluated by a structured interview. Diagnosis of gastric and duodenal ulcer as well as <jats:italic>Helicobacter pylori<\/jats:italic> infection were carried out by endoscopy and histological examination of the gastric mucosa.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002About 47.3% of patients were acute and 52.7% chronic users of non\u2010steroidal anti\u2010inflammatory drugs or aspirin. The risk of peptic ulcer, adjusted for age, gender, <jats:italic>H. pylori<\/jats:italic> infection and antisecretory drug use was higher in acute (gastric ulcer: odds ratio, OR\u2003=4.47, 95% CI: 3.19\u20136.26 and duodenal ulcer: OR\u2003=2.39, 95% CI: 1.73\u20133.31) than chronic users (gastric ulcer: OR\u2003=\u20032.80, 95% CI: 1.97\u20133.99 and duodenal ulcer: OR\u2003=\u20031.68, 95% CI: 1.22\u20132.33). Proton\u2010pump inhibitor treatment was associated with a reduced risk of peptic ulcer in both acute (OR\u2003=\u20030.70, 95% CI: 0.24\u20132.04) and chronic (OR\u2003=\u20030.32, 95% CI: 0.15\u20130.67) non\u2010steroidal anti\u2010inflammatory drugs\/aspirin users. Conversely, concomitant treatment with H<jats:sub>2<\/jats:sub>\u2010blockers was associated with a significantly higher risk of peptic ulcer both in acute (OR\u2003=\u200310.9, 95% CI: 3.87\u201330.9) and chronic (OR\u2003=\u20036.26, 95% CI: 2.56\u201315.3) non\u2010steroidal anti\u2010inflammatory drugs\/aspirin users than non\u2010users. Proton\u2010pump inhibitor treatment resulted in an absolute risk reduction of peptic ulcer by 36.6% in acute and 34.6% in chronic non\u2010steroidal anti\u2010inflammatory drugs\/aspirin users; indeed, the number needed to treat to avoid one peptic ulcer in elderly non\u2010steroidal anti\u2010inflammatory drugs\/aspirin users was three both in acute and chronic users.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002These findings suggest that proton\u2010pump inhibitor co\u2010treatment is advisable in symptomatic elderly patients who need to be treated with non\u2010steroidal anti\u2010inflammatory drugs and\/or aspirin for a short period of time.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2004.02246.x","type":"journal-article","created":{"date-parts":[[2005,3,10]],"date-time":"2005-03-10T04:17:50Z","timestamp":1110428270000},"page":"1091-1097","source":"Crossref","is-referenced-by-count":62,"title":["Proton\u2010pump inhibitors reduce the risk of uncomplicated peptic ulcer in elderly either acute or chronic users of aspirin\/non\u2010steroidal anti\u2010inflammatory drugs"],"prefix":"10.1111","volume":"20","author":[{"given":"A.","family":"Pilotto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Franceschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Leandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Paris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cascavilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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