{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:17:02Z","timestamp":1762175822281},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold> Management of high\u2010grade dysplasia in Barrett's oesophagus is controversial: surgery carries an appreciable morbidity\/mortality, high\u2010grade dysplasia may not progress to cancer and endoscopic ablation is an emerging option.<\/jats:p><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To review Barrett's oesophagus\u2010related high\u2010grade dysplasia management and outcome over a 10\u2010year period.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> This was a retrospective case note review of 36 patients identified from a pathology database.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> There were 31 men of mean age 67\u2003years. Endoscopic surveillance identified nine. Median follow\u2010up was 21\u2003months. Seven patients had no further intervention because of age\/comorbidity. The other 29 had repeat endoscopic biopsies, nine showing cancer (six oesophagectomized). Of the 20 remaining patients with persisting high\u2010grade dysplasia, eight had surgery (histology showed cancer in six), seven continued endoscopic surveillance (high\u2010grade dysplasia regressed in four) and five had \u2018curative\u2019 argon ablation. An intensive biopsy protocol was not followed in 55% of endoscopies. Prevalent cancers occurred in 44% with an annual incidence of 5% over 5\u2003years. All cause mortality was 39% (14 of 36, eight of 14 from cancer).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Management of high\u2010grade dysplasia was not uniform. Unsuspected cancer was common in high\u2010grade dysplasia patients undergoing surgery but 13% regressed under surveillance. High\u2010grade dysplasia patients have a high mortality but 43% did not die from cancer.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02401.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T11:03:21Z","timestamp":1111057401000},"page":"747-755","source":"Crossref","is-referenced-by-count":16,"title":["High\u2010grade dysplasia in Barrett's oesophagus: natural history and review of clinical practice"],"prefix":"10.1111","volume":"21","author":[{"given":"T.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"De Caestecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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