{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T09:21:55Z","timestamp":1773393715809,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To study features in older patients with autoimmune hepatitis, as this was considered mainly a disease of young females.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Analysis of 28 patients diagnosed at age \u226565\u2003years compared with 84 younger patients.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The incidence was similar at all age decades. The ratio M:F was 1\u2003:\u20033 (\u226565\u2003years) vs. 1\u2003:\u20032 (&lt;65\u2003years). Presenting symptoms were not different when compared with younger patients and consisted of general malaise and fatigue (36%), jaundice\u2003\u00b1\u2003other symptoms (50%), or ascites (11%). Antinuclear antibodies (ANA)\u2003\u2265\u20031\/80 were positive in 93%, smooth muscle antibodies (SMA)\u2003&gt;\u20031\/40 in 50%, anti\u2010liver kidney microsomes (anti\u2010LKM) proved always negative. Histology showed acute necrotizing hepatitis in 19%, severe interphase hepatitis in 15%, chronic hepatitis with plasmo\u2010lymphocytic infiltrate in 30%, cirrhosis in 29% (with active inflammation in one\u2010third); biopsy was refused in 11%. The elderly responded very well to low doses of methylprednisolone (\u22648\u2003mg) and azathioprine (1\u2003mg\/kg). This schedule obviates side\u2010effects such as infections seen with higher dosages.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Autoimmune hepatitis has to be also looked for in the elderly with acute and chronic hepatitis. The steroid therapy should be individualized but kept at a low dose.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02403.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T11:03:21Z","timestamp":1111057401000},"page":"695-699","source":"Crossref","is-referenced-by-count":40,"title":["Diagnosis and treatment of autoimmune hepatitis at age 65 and older"],"prefix":"10.1111","volume":"21","author":[{"given":"C.","family":"Verslype","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Buchel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Nevens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Van Steenbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Fevery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,3,17]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"8","volume-title":"Leber, Blutproteine und Nahrungseiweiss Stoffwechsel Krankheiten","author":"Waldenstr\u00f6m J","year":"1950"},{"key":"e_1_2_9_3_2","first-page":"327","volume-title":"Diseases of the Liver and Biliary System","author":"Sherlock S","year":"2002"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199604043341406"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180435"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/90.4.289"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/26.6.441"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03782.x"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(94)80251-3"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)90656-W"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80205-5"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-1-14"},{"key":"e_1_2_9_14_2","first-page":"627","volume-title":"Autoimmune Liver Diseases","author":"Lewis JH","year":"1998"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(99)80004-3"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)00057-X"},{"key":"e_1_2_9_17_2","first-page":"1232","article-title":"Drug and toxin\u2010induced bile duct disorders","volume":"15","author":"Geubel AP","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(85)80773-X"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(02)00329-X"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2002.30991"},{"key":"e_1_2_9_21_2","first-page":"1109","volume-title":"Oxford Textbook of Clinical Hepatology","author":"Manns MP","year":"1999"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199510123331502"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02403.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02403.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:55:21Z","timestamp":1697230521000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02403.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02403.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02403.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}