{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:20:06Z","timestamp":1791109206534,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T00:00:00Z","timestamp":1111017600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim:\u2002<\/jats:bold> To study the effects of infliximab on pregnancy and foetal outcome.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> We conducted a retrospective chart review of women with Crohn's disease treated intentionally with infliximab during pregnancy. The primary outcome measure was the occurrence of congenital malformations. Secondary outcome measures were the rate of premature birth, low\u2010birth weight, small for gestational age infants, intrauterine growth retardation and caesarean section.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Ten women were identified. Eight women received maintenance infliximab infusions throughout their pregnancy and two women received their initial infliximab infusions during pregnancy. All 10 pregnancies ended in live births. No infants had congenital malformations, intrauterine growth retardation or small for gestational age parameters. Three infants were premature and one had low\u2010birth weight. Eight women had a caesarean section.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> This is the first reported series of intentional infliximab use throughout pregnancy. These data, combined with other studies of inadvertent use of infliximab during pregnancy, suggest that the benefits of infliximab in achieving response and maintaining remission in mothers with Crohn's disease may outweigh the risk to the foetus of exposure to the drug. Further prospective data collection will be helpful to confirm these findings.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02405.x","type":"journal-article","created":{"date-parts":[[2005,3,17]],"date-time":"2005-03-17T11:03:21Z","timestamp":1111057401000},"page":"733-738","source":"Crossref","is-referenced-by-count":218,"title":["Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disease"],"prefix":"10.1111","volume":"21","author":[{"given":"U.","family":"Mahadevan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Sandborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. P.","family":"Terdiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. G.","family":"Binion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,3,17]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70056-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199710093371502"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08512-4"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03671.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-3-13"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(03)00334-7"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030815"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020888"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03987.x"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(01)03714-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(02)05276-0"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02983.x"},{"key":"e_1_2_7_14_2","first-page":"214","article-title":"One Year Outcome of Patients with Severe Psoriatic Arthritis Treated with Infliximab","volume":"43","author":"Dechant C","year":"2000","journal-title":"Arthritis Rheum"},{"key":"e_1_2_7_15_2","first-page":"241","article-title":"The use of disease modifying antirheumatic drugs in women with rheumatoid arthritis of childbearing age: a survey of practice patterns and pregnancy outcomes","volume":"30","author":"Chakravarty EF","year":"2003","journal-title":"J Rheumatol"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh264"},{"key":"e_1_2_7_17_2","first-page":"A54","article-title":"Safety of Infliximab in Crohn's disease: data from the 5000 \u2013 patient TREAT registry","volume":"126","author":"Lichtenstein G","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30186.x"},{"key":"e_1_2_7_19_2","first-page":"P258","article-title":"Infliximab levels in breast\u2010milk of a nursing Crohn's patient","volume":"96","author":"Peltier M","year":"2001","journal-title":"Am Coll Gastroenterol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02405.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02405.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T20:55:28Z","timestamp":1697230528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02405.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02405.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02405.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}