{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:52:07Z","timestamp":1763765527553},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Proton\u2010pump inhibitors are effective at preventing the acid component of gastro\u2010oesophageal refluxate from entering the oesophagus. It is not clear whether proton\u2010pump inhibitors prevent duodenogastro\u2010oesophageal reflux.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To measure oesophageal exposure to duodenogastro\u2010oesophageal refluxate while on proton\u2010pump inhibitors in patients with Barrett's oesophagus.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002Twenty\u2010five patients (23 male) with Barrett's oesophagus underwent 24\u2003h oesophageal pH and Bilitec 2000 monitoring while on omeprazole 40\u2003mg\/day (<jats:italic>n<\/jats:italic>\u2003=\u200319) or omeprazole 60\u2003mg\/day (<jats:italic>n<\/jats:italic>\u2003=\u20036). All patients were undergoing argon plasma ablation of their Barrett's epithelium as part of a clinical trial and the Bilitec measurements were only carried out after the ablation had been completed.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u200220 of 25 (80%) patients had a normal oesophageal pH profile. Fifteen of the 25 (60%) had abnormal oesophageal exposure to bile as measured by Bilitec 2000. Of the 20 patients who had a normal 24\u2003h oesophageal pH profile, 11 (55%) had pathological exposure to bile in their oesophagus.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002Complete acid suppression does not guarantee elimination of duodenogastro\u2010oesophageal reflux.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02406.x","type":"journal-article","created":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T10:58:55Z","timestamp":1112698735000},"page":"969-975","source":"Crossref","is-referenced-by-count":32,"title":["Normalization of oesophageal pH does not guarantee control of duodenogastro\u2010oesophageal reflux in Barrett's oesophagus"],"prefix":"10.1111","volume":"21","author":[{"given":"J. A.","family":"Todd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. K.","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"De Caestecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70025-8"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.11.1484"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.10.1093"},{"key":"e_1_2_6_5_2","first-page":"411","article-title":"Bile reflux in columnar\u2010lined Barrett's oesophagus","volume":"75","author":"Iftikhar SY","year":"1993","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00533.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.598"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1983.01390050027005"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90123-6"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)80116-0"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(95)80015-8"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820528"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03411-5"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.43.5.603"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70492-0"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-255X(98)80072-3"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.5.547"},{"key":"e_1_2_6_18_2","first-page":"537","article-title":"Gastroesophageal reflux and adenocarcinoma of the esophagus","volume":"341","author":"Marcus G.","year":"1999","journal-title":"N Engl J Med"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.6.776"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(87)71676-9"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01296082"},{"key":"e_1_2_6_22_2","first-page":"1532","article-title":"Optimal dosing of omeprazole 40\u2003mg daily: effects on gastric acid and esophageal pH and serum gastrin in healthy controls","volume":"91","author":"Kuo B","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_23_2","first-page":"413","article-title":"Omeprazole works best when used properly","volume":"8","author":"Castell DO.","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"e_1_2_6_24_2","first-page":"G1050","article-title":"Validation studies of Bilitec 2000: an ambulatory duodenogastric reflux monitoring system","volume":"267","author":"Vaezi MF","year":"1994","journal-title":"Am J Physiol"},{"key":"e_1_2_6_25_2","first-page":"A66","article-title":"The effects of argon plasma coagulation therapy for Barrett's epithelium on oesophageal motility","volume":"47","author":"Basu K","year":"2000","journal-title":"Gut"},{"key":"e_1_2_6_26_2","first-page":"419","article-title":"The significance of bile in reflux esophagitis","volume":"134","author":"Gillison EW","year":"1972","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_6_27_2","first-page":"525","article-title":"Role of bile salts and trypsin in the pathogenesis of experimental alkaline esophagitis","volume":"93","author":"Salo JA","year":"1983","journal-title":"Surgery"},{"key":"e_1_2_6_28_2","first-page":"662","article-title":"Taurodeoxycholate modulates the effects of pepsin and trypsin in experimental esophagitis","volume":"97","author":"Lillemoe KD","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01307977"},{"key":"e_1_2_6_30_2","first-page":"280","article-title":"Effect of bile salts and related compounds on isolated esophageal mucosa","volume":"87","author":"Kivilaakso E","year":"1980","journal-title":"Surgery"},{"key":"e_1_2_6_31_2","first-page":"61","article-title":"Role of luminal H+ in the pathogenesis of experimental esophagitis","volume":"92","author":"Salo J","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(83)90017-3"},{"key":"e_1_2_6_33_2","first-page":"276","article-title":"Role of the components of the gastroduodenal contents in experimental acid esophagitis","volume":"92","author":"Lillemoe KD","year":"1982","journal-title":"Surgery"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.22.4.306"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711330105"},{"key":"e_1_2_6_36_2","first-page":"6803","article-title":"Influence of esophagojejunostomy on the induction of adenocarcinoma of the distal esophagus in Sprague\u2010Dawley rats by subcutaneous injection of 2,6\u2010dimethylnitrosomorpholine","volume":"49","author":"Pera M","year":"1989","journal-title":"Cancer Res"},{"key":"e_1_2_6_37_2","first-page":"503","article-title":"Duodenoesophageal reflux and the development of esophageal adenocarcinoma in rats","volume":"111","author":"Attwood SE","year":"1992","journal-title":"Surgery"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199609000-00012"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.36.2.518-524.1982"},{"key":"e_1_2_6_40_2","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0140-6736(80)92826-3","article-title":"Effect of cimetidine on the gastric bacterial flora","volume":"1","author":"Ruddell WS","year":"1980","journal-title":"Lancet"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.289.6447.717"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.4.455"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208680"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.39.1.54"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02777700"},{"key":"e_1_2_6_46_2","first-page":"462","article-title":"Alteration of bile acid metabolism by cimetidine in healthy humans","volume":"44","author":"Shindo K","year":"1996","journal-title":"J Investig Med"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.42.2.266"},{"key":"e_1_2_6_48_2","first-page":"279","article-title":"Management of Barrett's esophagus free of dysplasia","volume":"9","author":"DeMeester TR.","year":"1997","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"e_1_2_6_49_2","first-page":"764","article-title":"Alkaline gastroesophageal reflux: implications in the development of complications in Barrett's columnar\u2010lined lower esophagus","volume":"106","author":"Attwood SE","year":"1989","journal-title":"Surgery"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199522240-00010"},{"key":"e_1_2_6_51_2","first-page":"143","article-title":"Histamine\u20102\u2010receptor antagonists and oesophageal cancer","volume":"6","author":"Fioretti F","year":"1997","journal-title":"Eur J Cancer Prev"},{"key":"e_1_2_6_52_2","first-page":"13","article-title":"Post\u2010cimetidine surveillance for up to ten years: incidence of carcinoma of the stomach and oesophagus","volume":"78","author":"Colin\u2010Jones DG","year":"1991","journal-title":"Q J Med"},{"key":"e_1_2_6_53_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.11.1558"},{"key":"e_1_2_6_54_2","first-page":"216","article-title":"The lack of association between adenocarcinoma of the esophagus and gastric surgery: a retrospective study","volume":"92","author":"Birgisson S","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_55_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530060048032"},{"key":"e_1_2_6_56_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903183401101"},{"key":"e_1_2_6_57_2","first-page":"960","article-title":"Gastric surgery does not increase the risk of developing Barrett's esophagus","volume":"92","author":"Parrilla P","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_6_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30228.x"},{"key":"e_1_2_6_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.41077.x"},{"key":"e_1_2_6_60_2","first-page":"A324","article-title":"Twenty four hour impedance and pH monitoring (24\u2010hr Imp\u2010pH) in the evaluation of GERD patients with persistent symptoms despite bid proton pump inhibitors (PPI): a multicentre study","volume":"126","author":"Shay S","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_6_61_2","first-page":"211","article-title":"Characteristics of partial gastrectomy (PG) patients with esophageal symptoms of duodenogastric reflux","volume":"90","author":"Sears RJ","year":"1995","journal-title":"Am J Gastroenterol"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02406.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02406.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T21:27:44Z","timestamp":1697232464000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02406.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02406.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02406.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}