{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:35:11Z","timestamp":1781811311654,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Anti\u2010<jats:italic>Saccharomyces cerevisiae<\/jats:italic> and perinuclear anti\u2010neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To determine the prevalence of anti\u2010<jats:italic>S. cerevisiae<\/jats:italic> and perinuclear anti\u2010neutrophil cytoplasmic autoantibodies in a large series of coeliac disease patients before and after gluten free diet, and to correlate anti\u2010<jats:italic>S. cerevisiae<\/jats:italic>\u2010positivity with intestinal mucosal damage.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002One hundred and five consecutive coeliac disease patients and 141 controls (22 ulcerative colitis, 24 Crohn's disease, 30 primary sclerosing cholangitis, 15 postenteritis syndrome, 50 blood donors) were tested for anti\u2010<jats:italic>S. cerevisiae<\/jats:italic> by enzyme\u2010linked immunosorbent assay and for perinuclear anti\u2010neutrophil cytoplasmic autoantibodies by indirect immunofluorescence.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002In coeliac disease anti\u2010<jats:italic>S. cerevisiae<\/jats:italic> (immunoglobulin G and\/or immunoglobulin A) were slightly less frequent (59%) than in Crohn's disease (75%, <jats:italic>P<\/jats:italic>\u2003= 0.16) and significantly more frequent than in ulcerative colitis (27%), primary sclerosing cholangitis (30%), postenteritis syndrome (26%) and blood donors (4%) (<jats:italic>P<\/jats:italic>\u2003=\u20030.009, <jats:italic>P<\/jats:italic>\u2003=\u20030.0002, <jats:italic>P<\/jats:italic>\u2003=\u20030.025, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). No correlation was found between anti\u2010<jats:italic>S. cerevisiae<\/jats:italic> and degree of mucosal damage. Perinuclear anti\u2010neutrophil cytoplasmic autoantibodies were detected only in one coeliac. After gluten free diet the disappearance of anti\u2010<jats:italic>S. cerevisiae<\/jats:italic>\u2010immunoglobulin A (93%) was more frequent than that of immunoglobulin G (17%, <jats:italic>P<\/jats:italic>\u2003= 0.0001); perinuclear anti\u2010neutrophil cytoplasmic autoantibodies disappeared in the only coeliac positive at diagnosis.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002More than half of untreated coeliacs are anti\u2010<jats:italic>S. cerevisiae<\/jats:italic>\u2010positive irrespective of the severity of mucosal damage. Differently from immunoglobulin A, anti\u2010<jats:italic>S. cerevisiae<\/jats:italic>\u2010immunoglobulin G persisted in more than 80% after gluten free diet. The high prevalence of anti\u2010<jats:italic>S. cerevisiae<\/jats:italic> in coeliac disease suggests that they may be the effect of a non\u2010specific immune response in course of chronic small bowel disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02417.x","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T11:16:14Z","timestamp":1111662974000},"page":"881-887","source":"Crossref","is-referenced-by-count":65,"title":["Anti\u2010<scp>Saccharomyces cerevisiae<\/scp> and perinuclear anti\u2010neutrophil cytoplasmic antibodies in coeliac disease before and after gluten\u2010free diet"],"prefix":"10.1111","volume":"21","author":[{"given":"A.","family":"Granito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Zauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Muratori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Grassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Bortolotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Petrolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Veronesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Gionchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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