{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T13:06:24Z","timestamp":1759496784558},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T00:00:00Z","timestamp":1111622400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To test the hypothesis that duodenal colonization represents the final crucial step in the development of <jats:italic>Helicobacter pylori<\/jats:italic> related duodenal ulcer.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002Patients with non\u2010ulcer dyspepsia who had gastric colonization by <jats:italic>H. pylori<\/jats:italic> were included in the study. At baseline endoscopy, we evaluated the prevalence of duodenal colonization (culture, urease testing and histology), and cytotoxin\u2010associated gene A status (polymerase chain reaction). No patients received eradication during 1\u2003year follow\u2010up. At this time, endoscopy was repeated and the incidence of duodenal ulcer was assessed.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Among 181 patients completing follow\u2010up, 53 (29%) had duodenal colonization: 72% of them were cytotoxin\u2010associated gene A positive, versus 37% patients without duodenal colonization (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Duodenal ulcer developed in 12 (22.6%) patients with duodenal colonization and in two (1.6%) without duodenal colonization (odds ratio for duodenal ulcer: 6.29, 95% confidence intervals 2.44\u201317.45). The incidence of duodenal ulcer was similar among cytotoxin\u2010associated gene A positive and cytotoxin\u2010associated gene A negative subjects with duodenal colonization: 21.05% versus 26.6%.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002The assessment of duodenal colonization by <jats:italic>H. pylori<\/jats:italic> in patients with non\u2010ulcer dyspepsia is strongly predictive for the subsequent development of duodenal ulcer and may help to stratify patients at risk for this disease.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02423.x","type":"journal-article","created":{"date-parts":[[2005,3,24]],"date-time":"2005-03-24T11:16:14Z","timestamp":1111662974000},"page":"909-915","source":"Crossref","is-referenced-by-count":21,"title":["<scp>Helicobacter pylori<\/scp> duodenal colonization is a strong risk factor for the development of duodenal ulcer"],"prefix":"10.1111","volume":"21","author":[{"given":"A.","family":"Pietroiusti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Luzzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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