{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:38:48Z","timestamp":1789137528350,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T00:00:00Z","timestamp":1112659200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002In patients with pruritus of cholestasis, response to conventional drug treatment may be unsatisfactory. Activation of 5\u2010hydroxytryptamine receptors on dermal sensory nerve\u2010endings plays a role in the perception of pruritus. The 5\u2010hydroxytryptamine<jats:sub>3<\/jats:sub> receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data.<\/jats:p><jats:p><jats:bold>Aim<\/jats:bold> :\u2002To determine whether ondansetron is effective in treating the pruritus of cholestasis.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002A total of 19 patients with resistant pruritus were randomized, double blind, to receive either ondansetron 8\u2003mg or placebo as a single intravenous bolus, followed by oral ondansetron 8\u2003mg or placebo twice daily for 5\u2003days. Patients\u2019 perception of pruritus was recorded hourly using a visual analogue scale, and scratching activity measured by means of a piezo\u2010electric crystal attached to the fingernail.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002Mean pruritus score using visual analogue scale and scratching activity were reduced on the first treatment day compared with baseline in both the ondansetron and placebo groups (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05), but there were no significant differences in mean pruritus perception or scratching activity between the two groups.<\/jats:p><jats:p><jats:bold>Conclusion<\/jats:bold> :\u2002Ondansetron was of no benefit in this group of pruritic patients during short\u2010term treatment.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02430.x","type":"journal-article","created":{"date-parts":[[2005,4,5]],"date-time":"2005-04-05T10:58:55Z","timestamp":1112698735000},"page":"1041-1045","source":"Crossref","is-referenced-by-count":62,"title":["A controlled trial of ondansetron in the pruritus of cholestasis"],"prefix":"10.1111","volume":"21","author":[{"given":"J. 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