{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:45:07Z","timestamp":1790426707382,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2005,4,22]],"date-time":"2005-04-22T00:00:00Z","timestamp":1114128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2005,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background<\/jats:bold> :\u2002Rectal bleeding after pelvic radiotherapy is often attributed to radiation proctitis and patients do not routinely undergo flexible endoscopy.<\/jats:p><jats:p><jats:bold>Aims<\/jats:bold> :\u2002To assess the significance of bleeding after radiotherapy.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> :\u2002We maintained a prospective register of all such patients referred to our endoscopy unit.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> :\u2002One hundred and thirty\u2010nine men (median age 70\u2003years; range 31\u201382), and 32 women (median age 61\u2003years; range 30\u201381) were referred with rectal bleeding (median 2\u2003years; range 0\u201321) after pelvic radiotherapy. Primary tumour sites were urological (<jats:italic>n<\/jats:italic>\u2003=\u2003139), gastrointestinal (<jats:italic>n<\/jats:italic>\u2003=\u20037) and gynaecological (<jats:italic>n<\/jats:italic>\u2003=\u200325). Ninety patients had bleeding alone; 81 had other symptoms. One hundred and forty\u2010one had typical radiation proctitis; in 65 this was the sole diagnosis; eight had cancer, nine had high\u2010risk adenomas, and six had three or more small adenomas. Ninety\u2010five other diagnoses were made. Eleven (73%) patients with advanced polyps or cancer required only flexible sigmoidoscopy to make the diagnosis, while four (27%) diagnoses were made only after colonoscopy; 47% of these patients had no other symptoms apart from rectal bleeding.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> :\u2002After pelvic radiotherapy, clinical symptoms are not reliable in differentiating between radiation proctitis alone or more significant pathology. It is mandatory that all patients with new onset rectal bleeding are investigated with, at least, flexible sigmoidoscopy.<\/jats:p>","DOI":"10.1111\/j.1365-2036.2005.02438.x","type":"journal-article","created":{"date-parts":[[2005,4,23]],"date-time":"2005-04-23T00:34:58Z","timestamp":1114216498000},"page":"1085-1090","source":"Crossref","is-referenced-by-count":29,"title":["The significance of rectal bleeding after pelvic radiotherapy"],"prefix":"10.1111","volume":"21","author":[{"given":"H. R. T.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vlavianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. P.","family":"Dearnaley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J. N.","family":"Andreyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,4,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.1909.272"},{"key":"e_1_2_7_3_2","first-page":"S12","article-title":"GI symptoms developing after pelvic radiotherapy require gastroenterological review but is that happening in the UK","volume":"15","author":"Andreyev HJN","year":"2003","journal-title":"Clin Oncol"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80458-0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19941101)74:9<2520::AID-CNCR2820740921>3.0.CO;2-Q"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05180-0"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01760.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(80)73265-0"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.217.1.r00oc24215"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018506"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(99)00173-5"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00080-7"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(99)70228-2"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199807000-00007"},{"key":"e_1_2_7_15_2","first-page":"273","article-title":"Tolerance of the intestine to radiation therapy","volume":"151","author":"Kinsella T","year":"1980","journal-title":"Surg Gynaecol Obstet"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(87)90008-3"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.265.9.1180"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450050059028"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.284.6314.449"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.19.1429"},{"key":"e_1_2_7_21_2","first-page":"2944","volume-title":"Cancer: Principles & Practice of Oncology","author":"Van Leeuwen FE","year":"2001"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00307-9"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<398::AID-CNCR22>3.0.CO;2-V"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970415)79:8<1600::AID-CNCR24>3.0.CO;2-0"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950801)76:3<442::AID-CNCR2820760315>3.0.CO;2-L"},{"key":"e_1_2_7_26_2","first-page":"955","article-title":"Second cancers following radiation treatment for cervical cancer: an international collaboration among cancer registries","volume":"74","author":"Boice J","year":"1985","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1177\/014107689008300308"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05724.x"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600360"},{"key":"e_1_2_7_30_2","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: is there any role for the gastroenterologist","author":"Andreyev HJN","journal-title":"Int J Radiol Biol Phys"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2036.2005.02438.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2036.2005.02438.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T22:07:44Z","timestamp":1697407664000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2036.2005.02438.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,22]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["10.1111\/j.1365-2036.2005.02438.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2036.2005.02438.x","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,22]]}}}